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Open AccessArticle

Lack of Additive Effects of Resveratrol and Energy Restriction in the Treatment of Hepatic Steatosis in Rats

Nutrition and Obesity Group, Department of Nutrition and Food Science, University of the Basque Country (UPV/EHU) and Lucio Lascaray Research Institute, Facultad de Farmacia, Vitoria 01006, Spain
CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Vitoria 01006, Spain
Department of Life Sciences and Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra 3004-517, Portugal
Author to whom correspondence should be addressed.
Nutrients 2017, 9(7), 737;
Received: 30 May 2017 / Revised: 3 July 2017 / Accepted: 5 July 2017 / Published: 11 July 2017
(This article belongs to the Special Issue Antioxidants in Health and Disease)
The aims of the present study were to analyze the effect of resveratrol on liver steatosis in obese rats, to compare the effects induced by resveratrol and energy restriction and to research potential additive effects. Rats were initially fed a high-fat high-sucrose diet for six weeks and then allocated in four experimental groups fed a standard diet: a control group, a resveratrol-treated group, an energy restricted group and a group submitted to energy restriction and treated with resveratrol. We measured liver triacylglycerols, transaminases, FAS, MTP, CPT1a, CS, COX, SDH and ATP synthase activities, FATP2/FATP5, DGAT2, PPARα, SIRT1, UCP2 protein expressions, ACC and AMPK phosphorylation and PGC1α deacetylation. Resveratrol reduced triacylglycerols compared with the controls, although this reduction was lower than that induced by energy restriction. The mechanisms of action were different. Both decreased protein expression of fatty acid transporters, thus suggesting reduced fatty acid uptake from blood stream and liver triacylglycerol delivery, but only energy restriction reduced the assembly. These results show that resveratrol is useful for liver steatosis treatment within a balanced diet, although its effectiveness is lower than that of energy restriction. However, resveratrol is unable to increase the reduction in triacylglycerol content induced by energy restriction. View Full-Text
Keywords: resveratrol; energy restriction; liver steatosis; rat resveratrol; energy restriction; liver steatosis; rat
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Milton-Laskibar, I.; Aguirre, L.; Fernández-Quintela, A.; Rolo, A.P.; Soeiro Teodoro, J.; Palmeira, C.M.; Portillo, M.P. Lack of Additive Effects of Resveratrol and Energy Restriction in the Treatment of Hepatic Steatosis in Rats. Nutrients 2017, 9, 737.

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