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Bone-Protective Effects of Dried Plum in Postmenopausal Women: Efficacy and Possible Mechanisms

1
Department of Nutrition, Food and Exercise Sciences, College of Human Sciences, Florida State University, Tallahassee, FL 32306, USA
2
Center for Advancing Exercise and Nutrition Research on Aging (CAENRA), College of Human Sciences, Florida State University, Tallahassee, FL 32306, USA
3
Department of Food Science and Human Nutrition, College of Health and Human Sciences, Colorado State University, Fort Collins, CO 80523, USA
4
Department of Nutrition, College of Graduate and Undergraduate Studies, Life University, Marietta, GA 30060, USA
5
School of Exercise and Nutritional Sciences, College of Health & Human Services, San Diego State University, San Diego, CA 92182, USA
6
Department of Behavioral Health and Nutrition, College of Health Sciences, University of Delaware, Newark, DE 19716, USA
*
Author to whom correspondence should be addressed.
Nutrients 2017, 9(5), 496; https://doi.org/10.3390/nu9050496
Received: 15 April 2017 / Revised: 11 May 2017 / Accepted: 12 May 2017 / Published: 14 May 2017
(This article belongs to the Special Issue Dietary Bioactives and Bone Health)
Osteoporosis is an age-related chronic disease characterized by a loss of bone mass and quality, and is associated with an increased risk of fragility fractures. Postmenopausal women are at the greatest risk of developing osteoporosis due to the cessation in ovarian hormone production, which causes accelerated bone loss. As the demographic shifts to a more aged population, a growing number of postmenopausal women will be afflicted with osteoporosis. Certain lifestyle factors, including nutrition and exercise, are known to reduce the risk of developing osteoporosis and therefore play an important role in bone health. In terms of nutrition, accumulating evidence suggests that dried plum (Prunus domestica L.) is potentially an efficacious intervention for preventing and reversing bone mass and structural loss in an ovariectomized rat model of osteoporosis, as well as in osteopenic postmenopausal women. Here, we provide evidence supporting the efficacy of dried plum in preventing and reversing bone loss associated with ovarian hormone deficiency in rodent models and in humans. We end with the results of a recent follow-up study demonstrating that postmenopausal women who previously consumed 100 g dried plum per day during our one-year clinical trial conducted five years earlier retained bone mineral density to a greater extent than those receiving a comparative control. Additionally, we highlight the possible mechanisms of action by which bioactive compounds in dried plum exert bone-protective effects. Overall, the findings of our studies and others strongly suggest that dried plum in its whole form is a promising and efficacious functional food therapy for preventing bone loss in postmenopausal women, with the potential for long-lasting bone-protective effects. View Full-Text
Keywords: bioactive compounds; functional foods; menopause; nutrition; polyphenols; (poly)phenols; prune; osteopenia; osteoporosis bioactive compounds; functional foods; menopause; nutrition; polyphenols; (poly)phenols; prune; osteopenia; osteoporosis
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Arjmandi, B.H.; Johnson, S.A.; Pourafshar, S.; Navaei, N.; George, K.S.; Hooshmand, S.; Chai, S.C.; Akhavan, N.S. Bone-Protective Effects of Dried Plum in Postmenopausal Women: Efficacy and Possible Mechanisms. Nutrients 2017, 9, 496.

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