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Consumption of Yogurt and the Incident Risk of Cardiovascular Disease: A Meta-Analysis of Nine Cohort Studies

by Lei Wu 1,* and Dali Sun 2
1
Department of Epidemiology, Institute of Geriatrics, Chinese People’s Liberation Army General Hospital, Beijing 100853, China
2
Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Nutrients 2017, 9(3), 315; https://doi.org/10.3390/nu9030315
Received: 10 February 2017 / Revised: 13 March 2017 / Accepted: 21 March 2017 / Published: 22 March 2017
(This article belongs to the Special Issue Prebiotics and Probiotics)
Previous systematic reviews and meta-analyses have evaluated the association of dairy consumption and the risk of cardiovascular disease (CVD). However, the findings were inconsistent. No quantitative analysis has specifically assessed the effect of yogurt intake on the incident risk of CVD. We searched the PubMed and the Embase databases from inception to 10 January 2017. A generic inverse-variance method was used to pool the fully-adjusted relative risks (RRs) and the corresponding 95% confidence intervals (CIs) with a random-effects model. A generalized least squares trend estimation model was used to calculate the specific slopes in the dose-response analysis. The present systematic review and meta-analysis identified nine prospective cohort articles involving a total of 291,236 participants. Compared with the lowest category, highest category of yogurt consumption was not significantly related with the incident risk of CVD, and the RR (95% CI) was 1.01 (0.95, 1.08) with an evidence of significant heterogeneity (I2 = 52%). However, intake of ≥200 g/day yogurt was significantly associated with a lower risk of CVD in the subgroup analysis. There was a trend that a higher level of yogurt consumption was associated with a lower incident risk of CVD in the dose-response analysis. A daily dose of ≥200 g yogurt intake might be associated with a lower incident risk of CVD. Further cohort studies and randomized controlled trials are still demanded to establish and confirm the observed association in populations with different characteristics. View Full-Text
Keywords: yogurt intake; stroke; coronary heart disease; cardiovascular disease; meta-analysis yogurt intake; stroke; coronary heart disease; cardiovascular disease; meta-analysis
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Wu, L.; Sun, D. Consumption of Yogurt and the Incident Risk of Cardiovascular Disease: A Meta-Analysis of Nine Cohort Studies. Nutrients 2017, 9, 315.

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