Next Article in Journal
Chemopreventive Potential of Raw and Roasted Pistachios Regarding Colon Carcinogenesis
Previous Article in Journal
Targeting NRF2 for Improved Skin Barrier Function and Photoprotection: Focus on the Achiote-Derived Apocarotenoid Bixin
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessArticle

Oligofructose Provides Laxation for Irregularity Associated with Low Fiber Intake

School of Health Studies, University of Memphis, Memphis, TN 38152, USA
BENEO-Institute, c/o BENEO GmbH, Wormser Str. 11, 67283 Obrigheim, Germany
Author to whom correspondence should be addressed.
Nutrients 2017, 9(12), 1372;
Received: 13 November 2017 / Revised: 30 November 2017 / Accepted: 13 December 2017 / Published: 18 December 2017
PDF [771 KB, uploaded 20 December 2017]


Inadequate dietary fiber intake contributes to the prevalent irregularity and constipation in Western countries. Although eating adequate amounts of fibers from fiber-rich foods, foods with added fibers and dietary fiber supplements is considered the first option for improving laxation, the efficacy can vary among types of fibers. The present study is a randomized control trial that included healthy adult participants with ≤3 bowel movements/week and a habitual low dietary fiber intake in a parallel design to evaluate the benefits for laxation by supplementing the daily diet with oligofructose (Orafti® P95; OF), a fermentable source of fiber and established prebiotic (n = 49); maltodextrin was the placebo (n = 48). After a run-in phase, OF was initially provided at 5 g/day, then increased to 10 and 15 g/day with four weeks for each phase. Stool frequency (bowel movements per week) for the OF and maltodextrin (MD) groups were initially similar (3.98 ± 1.49 vs. 4.06 ± 1.48), did not change for the placebo group, but increased for the OF group with the difference significant at 15 g/day (p = 0.023). Stool consistency was similar and remained unchanged at all doses for both groups. Gastrointestinal sensations were low for both groups. Laxation benefits were especially pronounced for participants with >13 g/day habitual dietary fiber intake, with significant laxation at 10 g and 15 g OF/day (p = 0.04 and p = 0.004, respectively) A daily supplement with a short-chain inulin-type fructan derived from chicory roots, i.e., oligofructose (Orafti® P95) provided a laxation effect without causing gastrointestinal (GI) distress for healthy participants with irregularity associated with low dietary fiber intake. View Full-Text
Keywords: constipation; fermentable; fiber; fructan; clinical trial; inulin; irregularity; laxation; supplement constipation; fermentable; fiber; fructan; clinical trial; inulin; irregularity; laxation; supplement

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Buddington, R.K.; Kapadia, C.; Neumer, F.; Theis, S. Oligofructose Provides Laxation for Irregularity Associated with Low Fiber Intake. Nutrients 2017, 9, 1372.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top