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Nutrients 2017, 9(12), 1353; https://doi.org/10.3390/nu9121353

Effect of Monthly, High-Dose, Long-Term Vitamin D on Lung Function: A Randomized Controlled Trial

1
School of Population Health, University of Auckland, Auckland 1072, New Zealand
2
Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
3
Department of General Practice, University of Otago, Christchurch 8011, New Zealand
4
Department of Public Health and Primary Care, University of Cambridge, Cambridge CB3 OEQ, UK
*
Author to whom correspondence should be addressed.
Received: 31 October 2017 / Revised: 7 December 2017 / Accepted: 8 December 2017 / Published: 13 December 2017
(This article belongs to the Special Issue Changing Times for Vitamin D and Health)
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Abstract

Although observational studies suggest positive vitamin D-lung function associations, randomized trials are inconsistent. We examined effects of vitamin D supplementation on lung function. We recruited 442 adults (50–84 years, 58% male) into a randomized, double-blinded, placebo-controlled trial. Participants received, for 1.1 years (median; range = 0.9–1.5 years), either (1) vitamin D3 200,000 IU, followed by monthly 100,000 IU doses (n = 226); or (2) placebo monthly (n = 216). At baseline and follow-up, spirometry yielded forced expiratory volume in 1 s (FEV1; primary outcome). Mean (standard deviation) 25-hydroxyvitamin D increased from 61 (24) nmol/L at baseline to 119 (45) nmol/L at follow-up in the vitamin D group, but was unchanged in the placebo group. There were no significant lung function improvements (vitamin D versus placebo) in the total sample, vitamin D-deficient participants or asthma/chronic obstructive pulmonary disease (COPD) participants. However, among ever-smokers (n = 217), the mean (95% confidence interval) FEV1 increase in the vitamin D versus placebo was 57 (4, 109) mL (p = 0.03). FEV1 increases were larger among vitamin D-deficient ever-smokers (n = 54): 122 (8, 236) mL (p = 0.04). FEV1 improvements were largest among ever-smokers with asthma/COPD (n = 60): 160 (53, 268) mL (p = 0.004). Thus, vitamin D supplementation did not improve lung function among everyone, but benefited ever-smokers, especially those with vitamin D deficiency or asthma/COPD. View Full-Text
Keywords: vitamin D; lung function; forced expiratory volume in 1 s; spirometry; randomized controlled trial vitamin D; lung function; forced expiratory volume in 1 s; spirometry; randomized controlled trial
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Sluyter, J.D.; Camargo, C.A., Jr.; Waayer, D.; Lawes, C.M.M.; Toop, L.; Khaw, K.-T.; Scragg, R. Effect of Monthly, High-Dose, Long-Term Vitamin D on Lung Function: A Randomized Controlled Trial. Nutrients 2017, 9, 1353.

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