Next Article in Journal
Antioxidant Effect of Barley Sprout Extract via Enhancement of Nuclear Factor-Erythroid 2 Related Factor 2 Activity and Glutathione Synthesis
Previous Article in Journal
Dietary Magnesium and Incident Frailty in Older People at Risk for Knee Osteoarthritis: An Eight-Year Longitudinal Study
Open AccessArticle

Evaluating Differences in Aluminum Exposure through Parenteral Nutrition in Neonatal Morbidities

University of North Carolina Health Care, Chapel Hill, NC 27514, USA
Wesley Children’s Hospital, 550 N Hillside, Wichita, KS 67214, USA
Saint Vincent Hospital, 123 Summer St, Worcester, MA 01608, USA
Author to whom correspondence should be addressed.
Nutrients 2017, 9(11), 1249;
Received: 2 October 2017 / Revised: 4 November 2017 / Accepted: 9 November 2017 / Published: 16 November 2017
Aluminum is a common contaminant in many components of parenteral nutrition, especially calcium and phosphate additives. Although long-term effects have been described in the literature, short-term effects are not well-known. Currently, the Food and Drug Administration recommends maintaining aluminum at <5 mcg/kg/day. This was a single center, retrospective case-control study of 102 neonatal intensive care unit patients. Patients were included if they had a diagnosis of necrotizing enterocolitis, rickets/osteopenia, or seizures and received at least 14 days of parenteral nutrition. Patients were matched 1:1 with control patients by gestational age and birth weight. Mean total aluminum exposure for the 14 days of parenteral nutrition was calculated using manufacturer label information. Differences in mean aluminum exposure between cases and controls, as well as subgroup analysis in those with renal impairment or cholestasis, was conducted. Aluminum exposure in patients meeting inclusion criteria closely mirrored the aluminum exposure of control patients. The difference in aluminum exposure was not found to be statistically significant, except in patients with cholestasis. Although the study found no difference in aluminum exposure in short-term complications with neonates, long-term complications are well established and may warrant the need to monitor and limit neonatal aluminum exposure. View Full-Text
Keywords: parenteral nutrition; aluminum; neonate parenteral nutrition; aluminum; neonate
MDPI and ACS Style

Fortenberry, M.; Hernandez, L.; Morton, J. Evaluating Differences in Aluminum Exposure through Parenteral Nutrition in Neonatal Morbidities. Nutrients 2017, 9, 1249.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop