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Nutrients 2017, 9(11), 1188;

Therapeutic Versatility of Resveratrol Derivatives

College of Pharmacy, Dalian Medical University, Dalian 116044,China
Academy of Integrative Medicine, Dalian Medical University, Dalian 116044, China
The Second Affiliated Hospital, Dalian Medical University, Dalian 116023, China
Authors to whom correspondence should be addressed.
Received: 15 August 2017 / Revised: 26 September 2017 / Accepted: 25 October 2017 / Published: 29 October 2017
(This article belongs to the Special Issue Effects of Resveratrol Supplementation on Human Health and Disease)
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Resveratrol, a natural phytoalexin, exhibits a remarkable range of biological activities, such as anticancer, cardioprotective, neuroprotective and antioxidant properties. However, the therapeutic application of resveratrol was encumbered for its low bioavailability. Therefore, many researchers focused on designing and synthesizing the derivatives of resveratrol to enhance the bioavailability and the pharmacological activity of resveratrol. During the past decades, a large number of natural and synthetic resveratrol derivatives were extensively studied, and the methoxylated, hydroxylated and halogenated derivatives of resveratrol received particular more attention for their beneficial bioactivity. So, in this review, we will summarize the chemical structure and the therapeutic versatility of resveratrol derivatives, and thus provide the related structure activity relationship reference for their practical applications. View Full-Text
Keywords: resveratrol; resveratrol derivatives; pharmacological activity; structure-activity relationship resveratrol; resveratrol derivatives; pharmacological activity; structure-activity relationship

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Nawaz, W.; Zhou, Z.; Deng, S.; Ma, X.; Ma, X.; Li, C.; Shu, X. Therapeutic Versatility of Resveratrol Derivatives. Nutrients 2017, 9, 1188.

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