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Nutrients 2017, 9(10), 1081;

Anti-Inflammatory Thioredoxin Family Proteins for Medicare, Healthcare and Aging Care

Japan Biostress Research Promotion Alliance (JBPA), 1-6 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8397, Japan
Institute for Virus Research, Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan
Department of Anatomy, Basic Medicine Science, Medical College, Shaoxing University, No 900 Cengnan Avenue, Shaoxing 312000, China
Terni Health Care University, 80-1 Bessho-cho, Tenri, Nara 632-0018, Japan
Author to whom correspondence should be addressed.
Received: 16 August 2017 / Revised: 19 September 2017 / Accepted: 25 September 2017 / Published: 29 September 2017
(This article belongs to the Special Issue Selected Papers from APNNO Biennial Conference 2016)
Full-Text   |   PDF [832 KB, uploaded 29 September 2017]   |  


Human thioredoxin (TRX) is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys-, which is induced by biological stress due to oxidative damage, metabolic dysfunction, chemicals, infection/inflammation, irradiation, or hypoxia/ischemia-reperfusion. Our research has demonstrated that exogenous TRX is effective in a wide variety of inflammatory diseases, including viral pneumonia, acute lung injury, gastric injury, and dermatitis, as well as in the prevention and amelioration of food allergies. Preclinical and clinical studies using recombinant TRX (rhTRX) are now underway. We have also identified substances that induce the expression of TRX in the body, in vegetables and other plant ingredients. Skincare products are being developed that take advantage of the anti-inflammatory and anti-allergic action of TRX. Furthermore, we are currently engaged in the highly efficient production of pure rhTRX in several plants, such as lettuce, grain and rice. View Full-Text
Keywords: inflammation; oxidative stress; redox; thioredoxin; thioredoxin-interacting protein inflammation; oxidative stress; redox; thioredoxin; thioredoxin-interacting protein

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Yodoi, J.; Matsuo, Y.; Tian, H.; Masutani, H.; Inamoto, T. Anti-Inflammatory Thioredoxin Family Proteins for Medicare, Healthcare and Aging Care. Nutrients 2017, 9, 1081.

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