Next Article in Journal
The Use of Fish Oil with Warfarin Does Not Significantly Affect either the International Normalised Ratio or Incidence of Adverse Events in Patients with Atrial Fibrillation and Deep Vein Thrombosis: A Retrospective Study
Next Article in Special Issue
Total Water Intake from Beverages and Foods Is Associated with Energy Intake and Eating Behaviors in Korean Adults
Previous Article in Journal
The Mediterranean Diet and Cognitive Function among Healthy Older Adults in a 6-Month Randomised Controlled Trial: The MedLey Study
Previous Article in Special Issue
Beverage Consumption Patterns among Norwegian Adults
Open AccessArticle

Fructose Beverage Consumption Induces a Metabolic Syndrome Phenotype in the Rat: A Systematic Review and Meta-Analysis

School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide 5000, SA, Australia
*
Author to whom correspondence should be addressed.
Nutrients 2016, 8(9), 577; https://doi.org/10.3390/nu8090577
Received: 27 July 2016 / Revised: 30 August 2016 / Accepted: 13 September 2016 / Published: 20 September 2016
A high intake of refined carbohydrates, particularly the monosaccharide fructose, has been attributed to the growing epidemics of obesity and type-2 diabetes. Animal studies have helped elucidate the metabolic effects of dietary fructose, however, variations in study design make it difficult to draw conclusions. The aim of this study was to review the effects of fructose beverage consumption on body weight, systolic blood pressure and blood glucose, insulin and triglyceride concentrations in validated rat models. We searched Ovid Embase Classic + EmbaseMedline and Ovid Medline databases and included studies that used adolescent/adult male rats, with fructose beverage consumption for >3 weeks. Data from 26 studies were pooled by an inverse variance weighting method using random effects models, expressed as standardized mean differences (SMD) with 95% confidence intervals (CI). Overall, 10%–21% w/v fructose beverage consumption was associated with increased rodent body weight (SMD, 0.62 (95% CI: 0.18, 1.06)), systolic blood pressure (SMD, 2.94 (95% CI: 2.10, 3.77)) and blood glucose (SMD, 0.77 (95% CI: 0.36, 1.19)), insulin (SMD, 2.32 (95% CI: 1.57, 3.07)) and triglyceride (SMD, 1.87 (95% CI: 1.39, 2.34)) concentrations. Therefore, the consumption of a low concentration fructose beverage is sufficient to cause early signs of the metabolic syndrome in adult rats. View Full-Text
Keywords: fructose; beverage; rat; metabolic syndrome; meta-analysis; diabetes; obesity fructose; beverage; rat; metabolic syndrome; meta-analysis; diabetes; obesity
Show Figures

Figure 1

MDPI and ACS Style

Toop, C.R.; Gentili, S. Fructose Beverage Consumption Induces a Metabolic Syndrome Phenotype in the Rat: A Systematic Review and Meta-Analysis. Nutrients 2016, 8, 577.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop