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Open AccessArticle

Prevalence and Predictors of Low Vitamin B6 Status in Healthy Young Adult Women in Metro Vancouver

by Chia-ling Ho 1,2, Teo A. W. Quay 1,2,†, Angela M. Devlin 2,3 and Yvonne Lamers 1,2,4,*
1
Food Nutrition and Health, Faculty of Land and Food Systems, The University of British Columbia, 2205 East Mall, Vancouver, BC V6T 1Z4, Canada
2
Research Institute, British Columbia Children’s Hospital, 950 West 28th Ave, Vancouver, BC V5Z 4H4, Canada
3
Department of Pediatrics, The University of British Columbia, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada
4
Fraser Health Authority, 10334 152A St, Surrey, BC V3R 7P8, Canada
*
Author to whom correspondence should be addressed.
Nutrients 2016, 8(9), 538; https://doi.org/10.3390/nu8090538
Received: 20 July 2016 / Revised: 23 August 2016 / Accepted: 25 August 2016 / Published: 1 September 2016
(This article belongs to the Special Issue B-Vitamins and One-Carbon Metabolism)
Low periconceptional vitamin B6 (B6) status has been associated with an increased risk of preterm birth and early pregnancy loss. Given many pregnancies are unplanned; it is important for women to maintain an adequate B6 status throughout reproductive years. There is limited data on B6 status in Canadian women. This study aimed to assess the prevalence of B6 deficiency and predictors of B6 status in young adult women in Metro Vancouver. We included a convenience sample of young adult non-pregnant women (19–35 years; n = 202). Vitamin B6 status was determined using fasting plasma concentrations of pyridoxal 5’-phosphate (PLP). Mean (95% confidence interval) plasma PLP concentration was 61.0 (55.2, 67.3) nmol/L. The prevalence of B6 deficiency (plasma PLP < 20 nmol/L) was 1.5% and that of suboptimal B6 status (plasma PLP = 20–30 nmol/L) was 10.9%. Body mass index, South Asian ethnicity, relative dietary B6 intake, and the use of supplemental B6 were significant predictors of plasma PLP. The combined 12.4% prevalence of B6 deficiency and suboptimal status was lower than data reported in US populations and might be due to the high socioeconomic status of our sample. More research is warranted to determine B6 status in the general Canadian population. View Full-Text
Keywords: vitamin B6; pyridoxal 5’-phosphate; suboptimal status; deficiency; ethnicity; dietary intake; supplement use; women; periconceptional vitamin B6; pyridoxal 5’-phosphate; suboptimal status; deficiency; ethnicity; dietary intake; supplement use; women; periconceptional
MDPI and ACS Style

Ho, C.-L.; Quay, T.A.W.; Devlin, A.M.; Lamers, Y. Prevalence and Predictors of Low Vitamin B6 Status in Healthy Young Adult Women in Metro Vancouver. Nutrients 2016, 8, 538.

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