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Article

Association of Vitamin B12 with Pro-Inflammatory Cytokines and Biochemical Markers Related to Cardiometabolic Risk in Saudi Subjects

1
Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
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Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
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Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
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Division of Biomedical Sciences, Warwick Medical School, University of Warwick, UHCW Trust, Clifford Bridge Road, Walsgrave, Coventry CV2 2DX, UK
5
Department of Biomedical Sciences, University of Westminster, London W1W 6UW, UK
*
Author to whom correspondence should be addressed.
Nutrients 2016, 8(9), 460; https://doi.org/10.3390/nu8090460
Received: 7 June 2016 / Revised: 17 August 2016 / Accepted: 30 August 2016 / Published: 6 September 2016
(This article belongs to the Special Issue B-Vitamins and One-Carbon Metabolism)
Background: This study aimed to examine the relationship between changes in systemic vitamin B12 concentrations with pro-inflammatory cytokines, anthropometric factors and biochemical markers of cardiometabolic risk in a Saudi population. Methods: A total of 364 subjects (224 children, age: 12.99 ± 2.73 (mean ± SD) years; BMI: 20.07 ± 4.92 kg/m2 and 140 adults, age: 41.87 ± 8.82 years; BMI: 31.65 ± 5.77 kg/m2) were studied. Fasting blood, anthropometric and biochemical data were collected. Serum cytokines were quantified using multiplex assay kits and B12 concentrations were measured using immunoassay analyzer. Results: Vitamin B12 was negatively associated with TNF-α (r = −0.14, p < 0.05), insulin (r = −0.230, p < 0.01) and HOMA-IR (r = −0.252, p < 0.01) in all subjects. In children, vitamin B12 was negatively associated with serum resistin (r = −0.160, p < 0.01), insulin (r = −0.248, p < 0.01), HOMA-IR (r = −0.261, p < 0.01). In adults, vitamin B12 was negatively associated with TNF-α (r = −0.242, p < 0.01) while positively associated with resistin (r = 0.248, p < 0.01). Serum resistin was the most significant predictor for circulating vitamin B12 in all subjects (r2 = −0.17, p < 0.05) and in children (r2 = −0.167, p < 0.01) while HDL-cholesterol was the predictor of B12 in adults (r2 = −0.78, p < 0.05). Conclusions: Serum vitamin B12 concentrations were associated with pro-inflammatory cytokines and biochemical markers of cardiometabolic risks in adults. Maintaining adequate vitamin B12 concentrations may lower inflammation-induced cardiometabolic risk in the Saudi adult population. View Full-Text
Keywords: vitamin B12; resistin; TNF-α; cardiometabolic diseases vitamin B12; resistin; TNF-α; cardiometabolic diseases
MDPI and ACS Style

Al-Daghri, N.M.; Rahman, S.; Sabico, S.; Yakout, S.; Wani, K.; Al-Attas, O.S.; Saravanan, P.; Tripathi, G.; McTernan, P.G.; Alokail, M.S. Association of Vitamin B12 with Pro-Inflammatory Cytokines and Biochemical Markers Related to Cardiometabolic Risk in Saudi Subjects. Nutrients 2016, 8, 460. https://doi.org/10.3390/nu8090460

AMA Style

Al-Daghri NM, Rahman S, Sabico S, Yakout S, Wani K, Al-Attas OS, Saravanan P, Tripathi G, McTernan PG, Alokail MS. Association of Vitamin B12 with Pro-Inflammatory Cytokines and Biochemical Markers Related to Cardiometabolic Risk in Saudi Subjects. Nutrients. 2016; 8(9):460. https://doi.org/10.3390/nu8090460

Chicago/Turabian Style

Al-Daghri, Nasser M., Shakilur Rahman, Shaun Sabico, Sobhy Yakout, Kaiser Wani, Omar S. Al-Attas, Ponnusamy Saravanan, Gyanendra Tripathi, Philip G. McTernan, and Majed S. Alokail. 2016. "Association of Vitamin B12 with Pro-Inflammatory Cytokines and Biochemical Markers Related to Cardiometabolic Risk in Saudi Subjects" Nutrients 8, no. 9: 460. https://doi.org/10.3390/nu8090460

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