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Retraction published on 23 May 2017, see Nutrients 2017, 9(6), 528.
Open AccessArticle

Post-Intake of S-Ethyl Cysteine and S-Methyl Cysteine Improved LPS-Induced Acute Lung Injury in Mice

by Te-chun Hsia 1,2 and Mei-chin Yin 3,4,*
1
Department of Respiratory Therapy, China Medical University, Taichung City 40402, Taiwan
2
Department of Internal Medicine, China Medical University Hospital, Taichung City 40402, Taiwan
3
Department of Nutrition, China Medical University, 91, Hsueh-shih Rd., Taichung City 40402, Taiwan
4
Department of Health and Nutrition Biotechnology, Asia University, Taichung City 41354, Taiwan
*
Author to whom correspondence should be addressed.
Nutrients 2016, 8(8), 507; https://doi.org/10.3390/nu8080507
Received: 21 June 2016 / Revised: 27 July 2016 / Accepted: 16 August 2016 / Published: 19 August 2016
The effects of S-ethyl cysteine (SEC) and S-methyl cysteine (SMC) on lipopolysaccharide (LPS)-induced acute lung injury in mice were examined. Eight hours after LPS challenge, SEC or SMC was supplied in drinking water at 0.5% or 1% for 3 days. LPS increased lung myeloperoxidase activity, neutrophil counts and edema. SEC or SMC post-intake attenuated these events. SEC or SMC suppressed LPS-induced lung expression of cyclooxygenase-2, nuclear factor-κB and mitogen-activated protein kinase, and lowered the generation of tumor necrosis factor-alpha, monocyte chemoattractant protein-1 and prostaglandin E2. LPS enhanced the expression of p47phox, gp91phox, Bax and cleaved caspase-3, and increased the production of reactive oxygen species in the lung. SEC or SMC post-intake reversed these alterations. These findings suggest that these agents could protect the lung through their anti-inflammatory, anti-oxidative and anti-apoptotic activities. View Full-Text
Keywords: S-ethyl cysteine; S-methyl cysteine; lung; LPS; inflammation S-ethyl cysteine; S-methyl cysteine; lung; LPS; inflammation
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Hsia, T.-C.; Yin, M.-C. Post-Intake of S-Ethyl Cysteine and S-Methyl Cysteine Improved LPS-Induced Acute Lung Injury in Mice. Nutrients 2016, 8, 507.

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