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Retraction published on 23 May 2017, see Nutrients 2017, 9(6), 528.
Open AccessArticle

Post-Intake of S-Ethyl Cysteine and S-Methyl Cysteine Improved LPS-Induced Acute Lung Injury in Mice

by Te-chun Hsia 1,2 and Mei-chin Yin 3,4,*
Department of Respiratory Therapy, China Medical University, Taichung City 40402, Taiwan
Department of Internal Medicine, China Medical University Hospital, Taichung City 40402, Taiwan
Department of Nutrition, China Medical University, 91, Hsueh-shih Rd., Taichung City 40402, Taiwan
Department of Health and Nutrition Biotechnology, Asia University, Taichung City 41354, Taiwan
Author to whom correspondence should be addressed.
Nutrients 2016, 8(8), 507;
Received: 21 June 2016 / Revised: 27 July 2016 / Accepted: 16 August 2016 / Published: 19 August 2016
The effects of S-ethyl cysteine (SEC) and S-methyl cysteine (SMC) on lipopolysaccharide (LPS)-induced acute lung injury in mice were examined. Eight hours after LPS challenge, SEC or SMC was supplied in drinking water at 0.5% or 1% for 3 days. LPS increased lung myeloperoxidase activity, neutrophil counts and edema. SEC or SMC post-intake attenuated these events. SEC or SMC suppressed LPS-induced lung expression of cyclooxygenase-2, nuclear factor-κB and mitogen-activated protein kinase, and lowered the generation of tumor necrosis factor-alpha, monocyte chemoattractant protein-1 and prostaglandin E2. LPS enhanced the expression of p47phox, gp91phox, Bax and cleaved caspase-3, and increased the production of reactive oxygen species in the lung. SEC or SMC post-intake reversed these alterations. These findings suggest that these agents could protect the lung through their anti-inflammatory, anti-oxidative and anti-apoptotic activities. View Full-Text
Keywords: S-ethyl cysteine; S-methyl cysteine; lung; LPS; inflammation S-ethyl cysteine; S-methyl cysteine; lung; LPS; inflammation
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Hsia, T.-C.; Yin, M.-C. Post-Intake of S-Ethyl Cysteine and S-Methyl Cysteine Improved LPS-Induced Acute Lung Injury in Mice. Nutrients 2016, 8, 507.

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