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Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Department of Occupational and Environmental health, Xiangya school of Public Health, Central South University, Changsha 410078, Hunan, China
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Nutrients 2016, 8(8), 483; https://doi.org/10.3390/nu8080483
Received: 1 June 2016 / Revised: 12 July 2016 / Accepted: 3 August 2016 / Published: 6 August 2016
It has been reported that gut probiotics play a major role in the bidirectional communication between the gut and the brain. Probiotics may be essential to people with depression, which remains a global health challenge, as depression is a metabolic brain disorder. However, the efficacy of probiotics for depression is controversial. This study aimed to systematically review the existing evidence on the effect of probiotics-based interventions on depression. Randomized, controlled trials, identified through screening multiple databases and grey literature, were included in the meta-analysis. The meta-analysis was performed using Review Manager 5.3 software using a fixed-effects model. The meta-analysis showed that probiotics significantly decreased the depression scale score (MD (depressive disorder) = −0.30, 95% CI (−0.51–−0.09), p = 0.005) in the subjects. Probiotics had an effect on both the healthy population (MD = −0.25, 95% CI (−0.47–−0.03), p = 0.03) and patients with major depressive disorder (MDD) (MD = −0.73, 95% CI (−1.37–−0.09), p = 0.03). Probiotics had an effect on the population aged under 60 (MD = −0.43, 95% CI (−0.72–−0.13), p = 0.005), while it had no effect on people aged over 65 (MD = −0.18, 95% CI (−0.47–0.11), p = 0.22). This is the first systematic review and meta-analysis with the goal of determining the effect of probiotics on depression. We found that probiotics were associated with a significant reduction in depression, underscoring the need for additional research on this potential preventive strategy for depression. View Full-Text
Keywords: probiotics; depression; meta-analysis; randomized controlled trial probiotics; depression; meta-analysis; randomized controlled trial
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MDPI and ACS Style

Huang, R.; Wang, K.; Hu, J. Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients 2016, 8, 483. https://doi.org/10.3390/nu8080483

AMA Style

Huang R, Wang K, Hu J. Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2016; 8(8):483. https://doi.org/10.3390/nu8080483

Chicago/Turabian Style

Huang, Ruixue, Ke Wang, and Jianan Hu. 2016. "Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials" Nutrients 8, no. 8: 483. https://doi.org/10.3390/nu8080483

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