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Caloric Restriction as a Strategy to Improve Vascular Dysfunction in Metabolic Disorders

1
The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm 17176, Sweden
2
Instituto Pluridisciplinar and Facultad de Farmacia, Universidad Complutense, Madrid 28040, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2016, 8(6), 370; https://doi.org/10.3390/nu8060370
Received: 13 March 2016 / Revised: 23 May 2016 / Accepted: 9 June 2016 / Published: 15 June 2016
(This article belongs to the Special Issue Diet and Metabolic Dysfunction)
Caloric restriction (CR) has proved to be the most effective and reproducible dietary intervention to increase healthy lifespan and aging. A reduction in cardiovascular disease (CVD) risk in obese subjects can be already achieved by a moderate and sustainable weight loss. Since pharmacological approaches for body weight reduction have, at present, a poor long-term efficacy, CR is of great interest in the prevention and/or reduction of CVD associated with obesity. Other dietary strategies changing specific macronutrients, such as altering carbohydrates, protein content or diet glycemic index have been also shown to decrease the progression of CVD in obese patients. In this review, we will focus on the positive effects and possible mechanisms of action of these strategies on vascular dysfunction. View Full-Text
Keywords: caloric restriction; dietary intervention; endothelial dysfunction; cardiovascular disease; obesity caloric restriction; dietary intervention; endothelial dysfunction; cardiovascular disease; obesity
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García-Prieto, C.F.; Fernández-Alfonso, M.S. Caloric Restriction as a Strategy to Improve Vascular Dysfunction in Metabolic Disorders. Nutrients 2016, 8, 370.

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