Next Article in Journal
Piceatannol and Other Wine Stilbenes: A Pool of Inhibitors against α-Synuclein Aggregation and Cytotoxicity
Previous Article in Journal
Nutrition and Cardiovascular Disease: Finding the Perfect Recipe for Cardiovascular Health
Open AccessFeature PaperCommentary

Effects of Dietary l-Arginine on Nitric Oxide Bioavailability in Obese Normotensive and Obese Hypertensive Subjects

1
Baker IDI Heart and Diabetes Institute, VIC 3004 Melbourne, Australia
2
Central Clinical School, Monash University, VIC 3004 Melbourne, Australia
3
Department of Biochemistry and Molecular Biology, Monash University, VIC 3004 Melbourne, Australia
4
Department of Physiology, Monash University, VIC 3004 Melbourne, Australia
*
Author to whom correspondence should be addressed.
Nutrients 2016, 8(6), 364; https://doi.org/10.3390/nu8060364
Received: 12 May 2016 / Revised: 2 June 2016 / Accepted: 7 June 2016 / Published: 14 June 2016
Obesity related hypertension is a major risk factor for resistant hypertension. We do not completely understand the mechanism(s) underlying the development of obesity related hypertension which hinders the development of novel treatment strategies for this condition. Data from experimental studies and small clinical trials indicate that transport of l-arginine, the substrate for nitric oxide (NO), and subsequent NO production are reduced in obesity induced hypertension. Reduced NO bioavailability can induce hypertension via multiple mechanisms. Mirmiran et al. recently analyzed data from a large population study and found that the association between dietary l-arginine and serum nitrate and nitrite was weakened in obese hypertensive subjects compared to obese normotensives. These data suggest that l-arginine dependent NO production is impaired in the former group compared to the latter which may represent a novel mechanism contributing to hypertension in the setting of obesity. View Full-Text
Keywords: l-arginine transport; nitric oxide; obesity related hypertension l-arginine transport; nitric oxide; obesity related hypertension
Show Figures

Figure 1

MDPI and ACS Style

Giam, B.; Kuruppu, S.; Head, G.A.; Kaye, D.M.; Rajapakse, N.W. Effects of Dietary l-Arginine on Nitric Oxide Bioavailability in Obese Normotensive and Obese Hypertensive Subjects. Nutrients 2016, 8, 364.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop