Effects of Dietary l-Arginine on Nitric Oxide Bioavailability in Obese Normotensive and Obese Hypertensive Subjects
1
Baker IDI Heart and Diabetes Institute, VIC 3004 Melbourne, Australia
2
Central Clinical School, Monash University, VIC 3004 Melbourne, Australia
3
Department of Biochemistry and Molecular Biology, Monash University, VIC 3004 Melbourne, Australia
4
Department of Physiology, Monash University, VIC 3004 Melbourne, Australia
*
Author to whom correspondence should be addressed.
Nutrients 2016, 8(6), 364; https://doi.org/10.3390/nu8060364
Received: 12 May 2016 / Revised: 2 June 2016 / Accepted: 7 June 2016 / Published: 14 June 2016
Obesity related hypertension is a major risk factor for resistant hypertension. We do not completely understand the mechanism(s) underlying the development of obesity related hypertension which hinders the development of novel treatment strategies for this condition. Data from experimental studies and small clinical trials indicate that transport of l-arginine, the substrate for nitric oxide (NO), and subsequent NO production are reduced in obesity induced hypertension. Reduced NO bioavailability can induce hypertension via multiple mechanisms. Mirmiran et al. recently analyzed data from a large population study and found that the association between dietary l-arginine and serum nitrate and nitrite was weakened in obese hypertensive subjects compared to obese normotensives. These data suggest that l-arginine dependent NO production is impaired in the former group compared to the latter which may represent a novel mechanism contributing to hypertension in the setting of obesity.
View Full-Text
▼
Show Figures
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Giam, B.; Kuruppu, S.; Head, G.A.; Kaye, D.M.; Rajapakse, N.W. Effects of Dietary l-Arginine on Nitric Oxide Bioavailability in Obese Normotensive and Obese Hypertensive Subjects. Nutrients 2016, 8, 364. https://doi.org/10.3390/nu8060364
AMA Style
Giam B, Kuruppu S, Head GA, Kaye DM, Rajapakse NW. Effects of Dietary l-Arginine on Nitric Oxide Bioavailability in Obese Normotensive and Obese Hypertensive Subjects. Nutrients. 2016; 8(6):364. https://doi.org/10.3390/nu8060364
Chicago/Turabian StyleGiam, Beverly; Kuruppu, Sanjaya; Head, Geoffrey A.; Kaye, David M.; Rajapakse, Niwanthi W. 2016. "Effects of Dietary l-Arginine on Nitric Oxide Bioavailability in Obese Normotensive and Obese Hypertensive Subjects" Nutrients 8, no. 6: 364. https://doi.org/10.3390/nu8060364
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Search more from Scilit