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A Randomised, Cross-Over Study to Estimate the Influence of Food on the 25-Hydroxyvitamin D3 Serum Level after Vitamin D3 Supplementation

Department of Clinical Chemistry, University of Liège, CHU Sart-Tilman, Liège 4000, Belgium
Department of Clinical Pharmacology, ATC SA, Liège 4000, Belgium
Clinical Department, Laboratoires SMB SA, Brussels 1080, Belgium
Laboratoire d’Explorations Fonctionnelles, Hôpital Necker-Enfants Malades, Paris 75014, France
Author to whom correspondence should be addressed.
Nutrients 2016, 8(5), 309;
Received: 29 February 2016 / Revised: 30 April 2016 / Accepted: 13 May 2016 / Published: 20 May 2016
Vitamin D3 is known to be liposoluble and its release could be a factor limiting the rate of absorption. It was presumed that the presence of fat could favor absorption of vitamin D3. However, as bioavailability is related not only to the active molecules but also to the formulations and excipients used, the optimization of the pharmaceutical form of vitamin D3 is also important. The objective of this study was to evaluate if there is a food effect on absorption when a high dose of vitamin D3 is completely solubilized in an oily solution. In the present cross-over study, 88 subjects were randomized and received a single dose of 50,000 IU of vitamin D3 in fasting state or with a standardized high-fat breakfast. Assessment of serum concentrations of 25 hydroxyvitamin D3 (25(OH)D3) was performed three, five, seven, 14, 30 and 60 days after supplementation. In fed and fast conditions, the 25(OH)D3 serum concentrations were significantly higher than the baseline value three days after administration and remained significantly higher during the first month. No significant difference between fasting vs. fed conditions was observed. It is therefore concluded that the vitamin D3 absorption from an oily solution was not influenced by the presence or absence of a meal. View Full-Text
Keywords: 25-hydroxyvitamin D3; absorption; high fat; fasting 25-hydroxyvitamin D3; absorption; high fat; fasting
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Cavalier, E.; Jandrain, B.; Coffiner, M.; Da Silva, S.; De Niet, S.; Vanderbist, F.; Souberbielle, J.-C. A Randomised, Cross-Over Study to Estimate the Influence of Food on the 25-Hydroxyvitamin D3 Serum Level after Vitamin D3 Supplementation. Nutrients 2016, 8, 309.

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