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Role of Vitamin D in Cognitive Function in Chronic Kidney Disease

by Zhen Cheng 1,2,†, Jing Lin 2,3,† and Qi Qian 2,*
1
National Clinical Research Center of Kidney Disease, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210016, China
2
Division of Nephrology and Hypertension Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
3
Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2016, 8(5), 291; https://doi.org/10.3390/nu8050291
Received: 30 March 2016 / Revised: 23 April 2016 / Accepted: 4 May 2016 / Published: 13 May 2016
Both vitamin D deficiency and cognitive impairment are common in patients with chronic kidney disease (CKD). Vitamin D exerts neuroprotective and regulatory roles in the central nervous system. Hypovitaminosis D has been associated with muscle weakness and bone loss, cardiovascular diseases (hypertension, diabetes and hyperlipidemia), inflammation, oxidative stress, immune suppression and neurocognitive impairment. The combination of hypovitaminosis D and CKD can be even more debilitating, as cognitive impairment can develop and progress through vitamin D-associated and CKD-dependent/independent processes, leading to significant morbidity and mortality. Although an increasingly recognized comorbidity in CKD, cognitive impairment remains underdiagnosed and often undermanaged. Given the association of cognitive decline and hypovitaminosis D and their deleterious effects in CKD patients, determination of vitamin D status and when appropriate, supplementation, in conjunction with neuropsychological screening, should be considered integral to the clinical care of the CKD population. View Full-Text
Keywords: vitamin D; hypovitaminosis D; cognitive impairment; chronic kidney disease; dialysis vitamin D; hypovitaminosis D; cognitive impairment; chronic kidney disease; dialysis
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Cheng, Z.; Lin, J.; Qian, Q. Role of Vitamin D in Cognitive Function in Chronic Kidney Disease. Nutrients 2016, 8, 291.

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