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Nutrients 2016, 8(5), 291;

Role of Vitamin D in Cognitive Function in Chronic Kidney Disease

National Clinical Research Center of Kidney Disease, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210016, China
Division of Nephrology and Hypertension Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 30 March 2016 / Revised: 23 April 2016 / Accepted: 4 May 2016 / Published: 13 May 2016
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Both vitamin D deficiency and cognitive impairment are common in patients with chronic kidney disease (CKD). Vitamin D exerts neuroprotective and regulatory roles in the central nervous system. Hypovitaminosis D has been associated with muscle weakness and bone loss, cardiovascular diseases (hypertension, diabetes and hyperlipidemia), inflammation, oxidative stress, immune suppression and neurocognitive impairment. The combination of hypovitaminosis D and CKD can be even more debilitating, as cognitive impairment can develop and progress through vitamin D-associated and CKD-dependent/independent processes, leading to significant morbidity and mortality. Although an increasingly recognized comorbidity in CKD, cognitive impairment remains underdiagnosed and often undermanaged. Given the association of cognitive decline and hypovitaminosis D and their deleterious effects in CKD patients, determination of vitamin D status and when appropriate, supplementation, in conjunction with neuropsychological screening, should be considered integral to the clinical care of the CKD population. View Full-Text
Keywords: vitamin D; hypovitaminosis D; cognitive impairment; chronic kidney disease; dialysis vitamin D; hypovitaminosis D; cognitive impairment; chronic kidney disease; dialysis

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Cheng, Z.; Lin, J.; Qian, Q. Role of Vitamin D in Cognitive Function in Chronic Kidney Disease. Nutrients 2016, 8, 291.

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