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Consumption of the Soluble Dietary Fibre Complex PolyGlycopleX® Reduces Glycaemia and Increases Satiety of a Standard Meal Postprandially

School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia 6845, Australia
Flinders Centre for Innovation in Cancer, School of Medicine, Flinders University, Adelaide 5001, Australia
Factors Group R & D, Burnaby, BC V3N 4S9, Canada
InovoBiologic Inc., Calgary, AB Y2N 4Y7, Canada
Food, Nutrition and Health Program, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
Author to whom correspondence should be addressed.
Nutrients 2016, 8(5), 268;
Received: 9 February 2016 / Revised: 27 March 2016 / Accepted: 29 April 2016 / Published: 6 May 2016
The effect of consumption of PolyGlycopleX® (PGX®) was compared to wheat dextrin (WD) in combination with a standard meal, on postprandial satiety and glycaemia in a double-blind, randomised crossover trial, of 14 healthy subjects trained as a satiety panel. At each of six two-hour satiety sessions, subjects consumed one of three different test meals on two separate occasions. The test meals were: a standard meal plus 5 g PGX; a standard meal plus 4.5 g of PGX as softgels; and a standard meal plus 5 g of WD. Subjects recorded fullness using a labelled magnitude scale at 0, 15, 30, 45, 60, 90, and 120 min and the total area under the curve (AUC), mean fullness vs. time was calculated. The meals with PGX (in granular and softgel form) gave higher satiety (AUC) (477 ± 121 and 454 ± 242 cm·min), than the meal with WD (215 ± 261 cm·min) (p < 0.001). Subjects had blood glucose levels measured after the meals with PGX (granules) and WD. Glucose response (AUC) was significantly lower (p < 0.001) after the PGX meal than for the WD meal. The high viscosity reported for PGX is a likely mechanism behind the significant satiety and blood glucose modulating effects observed in this study. View Full-Text
Keywords: PGX; dextrin; glycaemia; fibre; satiety PGX; dextrin; glycaemia; fibre; satiety
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Solah, V.A.; O’Mara-Wallace, B.; Meng, X.; Gahler, R.J.; Kerr, D.A.; James, A.P.; Fenton, H.K.; Johnson, S.K.; Wood, S. Consumption of the Soluble Dietary Fibre Complex PolyGlycopleX® Reduces Glycaemia and Increases Satiety of a Standard Meal Postprandially. Nutrients 2016, 8, 268.

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