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Open AccessArticle

Cohort Analysis of a 24-Week Randomized Controlled Trial to Assess the Efficacy of a Novel, Partial Meal Replacement Program Targeting Weight Loss and Risk Factor Reduction in Overweight/Obese Adults

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Food and Nutrition, Commonwealth Scientific and Industrial Research Organization (CSIRO), PO Box 10041, Adelaide, South Australia 5000, Australia
2
Health and Biosecurity, CSIRO, GPO Box 76, Epping, New South Wales 1710, Australia
*
Author to whom correspondence should be addressed.
Nutrients 2016, 8(5), 265; https://doi.org/10.3390/nu8050265
Received: 15 March 2016 / Revised: 8 April 2016 / Accepted: 14 April 2016 / Published: 4 May 2016
Our aim was to design and evaluate a weight-loss program, including a partial meal replacement program, point-of-care testing and face-to-face and smartphone app support, appropriate for delivery in a community pharmacy setting. Overweight or obese adults (n = 146, 71.2% female, 48.18 ± 11.75 years old) were recruited to participate in a 24-week weight loss study and randomised to two app conditions. The dietary intervention was consistent regardless of app. Twelve weeks of clinic appointments with a trained consultant were followed by only app support for an additional 12 weeks. By week 24, retention was 57.5%. There were no differences between app conditions. Based on a cohort analysis of the trial, the mean decrease in weight from baseline to week 24 was 6.43 ± 1.06 kg for males (p < 0.001) and 5.66 ± 0.70 kg for females (p < 0.001). Mixed models also revealed decreases for LDL Cholesterol (−0.13 ± 0.08 mmol/L, nonsignificant), triglycerides (−0.08 ± 0.05 mmol/L, nonsignificant) and an increase in HDL cholesterol (+0.08 ± 0.04 mmol/L, ns) were not significant by week 24. Blood glucose (−0.23 ± 0.08 mmol/L, p = 0.040) and blood pressure (Systolic blood pressure −5.77 ± 1.21 Hg/mm, p < 0.001) were significantly lower at week 24 compared to baseline. Weight loss self-efficacy increased and remained significantly higher than baseline at week 24 (16.85 ± 2.93, p < 0.001). Overall, the program supported participants and was successful in achieving significant weight loss and improvements in health outcomes over 24 weeks. View Full-Text
Keywords: meal replacement; diet; smartphone; weight loss; pharmacy meal replacement; diet; smartphone; weight loss; pharmacy
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MDPI and ACS Style

Brindal, E.; Hendrie, G.A.; Taylor, P.; Freyne, J.; Noakes, M. Cohort Analysis of a 24-Week Randomized Controlled Trial to Assess the Efficacy of a Novel, Partial Meal Replacement Program Targeting Weight Loss and Risk Factor Reduction in Overweight/Obese Adults. Nutrients 2016, 8, 265.

AMA Style

Brindal E, Hendrie GA, Taylor P, Freyne J, Noakes M. Cohort Analysis of a 24-Week Randomized Controlled Trial to Assess the Efficacy of a Novel, Partial Meal Replacement Program Targeting Weight Loss and Risk Factor Reduction in Overweight/Obese Adults. Nutrients. 2016; 8(5):265.

Chicago/Turabian Style

Brindal, Emily; Hendrie, Gilly A.; Taylor, Pennie; Freyne, Jill; Noakes, Manny. 2016. "Cohort Analysis of a 24-Week Randomized Controlled Trial to Assess the Efficacy of a Novel, Partial Meal Replacement Program Targeting Weight Loss and Risk Factor Reduction in Overweight/Obese Adults" Nutrients 8, no. 5: 265.

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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