Origanum majorana Attenuates Nephrotoxicity of Cisplatin Anticancer Drug through Ameliorating Oxidative Stress
Abstract
:1. Introduction
2. Materials and Methods
2.1. Chemicals
2.2. Preparation of Origanum Majorana Ethanolic Extract
2.3. Animals
2.4. Experimental Design
2.5. Animal Handling
2.6. Tissue Preparation
2.7. Evaluation of in VivoAntinephrotoxic Activity of OMEE
2.8. Evaluation of in Vivo Antioxidant Capacity of OMEE
2.9. Histological Examination
2.10. Statistical Analysis
3. Results
3.1. Effect of OMEE Treatment on the Nephrotoxicity Induced by CDDP
3.2. In Vivo Antioxidant Potency of OMEE
3.3. Histopathology of Rat Kidney
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Markers | Control | CDDP | |||
---|---|---|---|---|---|
Vehicle | OMEE | ||||
Creatinine | (mg/dL) | 0.448 ± 0.013 | 0.727 ± 0.047 a | 0.465 ± 0.027 b | (−57.78%) |
Urea | (g/dL) | 38.145 ± 1.065 | 54.598 ± 4.042 a | 33.466 ± 1.451 b | (−42.87%) |
Uric acid | (mg/dL) | 2.148 ± 0.081 | 2.742 ± 0.165 a | 1.926 ± 0.212 b | (−42.87%) |
BUN | (g/dL) | 81.718 ± 2.278 | 116.911 ± 8.654 a | 81.879± 6.303 b | (−37.67%) |
Markers | Control | CDDP | |||
---|---|---|---|---|---|
Vehicle | OMEE | ||||
MDA | (nmol/g.protein) | 5.937 ± 0.595 | 12.029 ± 0.711 a | 5.628 ± 0.527 b | (−107.74%) |
NO | (Mmol/g.protein) | 171.602 ± 9.944 | 312.555 ± 19.110 a | 187.258 ± 24.846 b | (−73.02%) |
GSH | (mg/g.protein) | 22.719 ± 2.885 | 13.621 ± 2.098 a | 22.378 ± 1.591 b | (38.56%) |
SOD | (U/g.protein) | 993.255 ± 74.932 | 655.220 ± 87.654 a | 991.462 ± 105.168 b | (35.42%) |
CAT | (U/g.protein) | 11.054 ± 0.502 | 5.730 ± 0.776 a | 11.081 ± 1.161 b | (48.42%) |
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Soliman, A.M.; Desouky, S.; Marzouk, M.; Sayed, A.A. Origanum majorana Attenuates Nephrotoxicity of Cisplatin Anticancer Drug through Ameliorating Oxidative Stress. Nutrients 2016, 8, 264. https://doi.org/10.3390/nu8050264
Soliman AM, Desouky S, Marzouk M, Sayed AA. Origanum majorana Attenuates Nephrotoxicity of Cisplatin Anticancer Drug through Ameliorating Oxidative Stress. Nutrients. 2016; 8(5):264. https://doi.org/10.3390/nu8050264
Chicago/Turabian StyleSoliman, Amel M., Shreen Desouky, Mohamed Marzouk, and Amany A. Sayed. 2016. "Origanum majorana Attenuates Nephrotoxicity of Cisplatin Anticancer Drug through Ameliorating Oxidative Stress" Nutrients 8, no. 5: 264. https://doi.org/10.3390/nu8050264