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Nutrients 2016, 8(5), 264;

Origanum majorana Attenuates Nephrotoxicity of Cisplatin Anticancer Drug through Ameliorating Oxidative Stress

Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt
Author to whom correspondence should be addressed.
Received: 16 February 2016 / Revised: 28 April 2016 / Accepted: 29 April 2016 / Published: 5 May 2016
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Despite the fact that cisplatin is an important anticancer drug, its clinical utilization is limited by nephrotoxicity during long term medication. Combined cisplatin chemotherapy with plant extracts can diminish toxicity and enhance the antitumor efficacy of the drug. This study evaluated the effect of Originum majorana ethanolic extract (OMEE) on cisplatin-induced nephrotoxicity. Eighteen male rats were divided into three groups as follows: a control group, a group treated with cisplatin (3 mg/kg body weight), and a group that received both cisplatin and OMEE (500 mg/kg body weight) for 14 days. Cisplatin induced a significant increase in creatinine, urea, uric acid, blood urea nitrogen, malondialdehyde, and nitric oxide levels. However, glutathione, superoxide dismutase, and catalase levels were significantly diminished. Conversely, OMEE significantly modulated the renal and oxidative markers negatively impacted by cisplatin. OMEE significantly reduced the effects of cisplatin-induced changes in renal and oxidative markers, possibly through its free radical scavenging activity. Thus, OMEE may be combined with cisplatin to alleviate nephrotoxicity in cancer chemotherapy. View Full-Text
Keywords: cisplatin; nephrotoxicity; Originum majorana; oxidative stress cisplatin; nephrotoxicity; Originum majorana; oxidative stress

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Soliman, A.M.; Desouky, S.; Marzouk, M.; Sayed, A.A. Origanum majorana Attenuates Nephrotoxicity of Cisplatin Anticancer Drug through Ameliorating Oxidative Stress. Nutrients 2016, 8, 264.

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