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Article

n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease

1
School of Medicine and Pharmacology, Royal Perth Hospital, University of Western Australia, Perth 6000, Western Australia, Australia
2
CSIRO Food and Nutrition, Adelaide 5000, South Australia, Australia
3
Department of Nephrology and Transplantation, Fiona Stanley Hospital, Murdoch 6150, Western Australia, Australia
4
Telethon Kids Institute, Subiaco 6008, Western Australia, Australia
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2016, 8(3), 175; https://doi.org/10.3390/nu8030175
Received: 17 December 2015 / Revised: 8 March 2016 / Accepted: 17 March 2016 / Published: 19 March 2016
DNA telomere shortening associates with the age-related increase cardiovascular disease (CVD) risk. Reducing oxidative stress, could modify telomere erosion during cell replication, and CVD risk in patients with chronic kidney disease (CKD). The effect of n-3 fatty acids and coenzyme Q10 (CoQ) on telomere length was studied in a double-blind placebo-controlled trial in CKD. Eighty-five CKD patients were randomized to: n-3 fatty acids (4 g); CoQ (200 mg); both supplements; or control (4 g olive oil), daily for 8 weeks. Telomere length was measured in neutrophils and peripheral blood mononuclear cells (PBMC) at baseline and 8 weeks, with and without correction for cell counts. Main and interactive effects of n-3 fatty acids and CoQ on telomere length were assessed adjusting for baseline values. F2-isoprostanes were measured as markers of oxidative stress. There was no effect of n-3 fatty acids or CoQ on neutrophil or PBMC telomere length. However, telomere length corrected for neutrophil count was increased after n-3 fatty acids (p = 0.015). Post-intervention plasma F2-isoprostanes were negative predictors of post-intervention telomere length corrected for neutrophil count (p = 0.025).The effect of n-3 fatty acids to increased telomere length corrected for neutrophil count may relate to reduced oxidative stress and increased clearance of neutrophils with shorter telomeres from the circulation. This may be a novel mechanism of modifying CVD risk in CKD patients. View Full-Text
Keywords: neutrophils; telomere length; oxidative stress; n-3 fatty acids; coenzyme Q10 neutrophils; telomere length; oxidative stress; n-3 fatty acids; coenzyme Q10
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MDPI and ACS Style

Barden, A.; O’Callaghan, N.; Burke, V.; Mas, E.; Beilin, L.J.; Fenech, M.; Irish, A.B.; Watts, G.F.; Puddey, I.B.; Huang, R.-C.; Mori, T.A. n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease. Nutrients 2016, 8, 175. https://doi.org/10.3390/nu8030175

AMA Style

Barden A, O’Callaghan N, Burke V, Mas E, Beilin LJ, Fenech M, Irish AB, Watts GF, Puddey IB, Huang R-C, Mori TA. n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease. Nutrients. 2016; 8(3):175. https://doi.org/10.3390/nu8030175

Chicago/Turabian Style

Barden, Anne, Nathan O’Callaghan, Valerie Burke, Emile Mas, Lawrence J. Beilin, Michael Fenech, Ashley B. Irish, Gerald F. Watts, Ian B. Puddey, Rae-Chi Huang, and Trevor A. Mori 2016. "n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease" Nutrients 8, no. 3: 175. https://doi.org/10.3390/nu8030175

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