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Anti-Diabetic Activities of Gastrodia elata Blume Water Extracts Are Mediated Mainly by Potentiating Glucose-Stimulated Insulin Secretion and Increasing β-Cell Mass in Non-Obese Type 2 Diabetic Animals

1
Food Functional Research Division, Korean Food Research Institutes, Sungnam 463-746, Korea
2
Department of Food and Nutrition, Obesity/Diabetes Center, Hoseo University, Asan 336-795, Korea
3
Department of Nanobiomechatronics, Hoseo University, Asan 336-795, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2016, 8(3), 161; https://doi.org/10.3390/nu8030161
Received: 14 January 2016 / Revised: 27 February 2016 / Accepted: 9 March 2016 / Published: 11 March 2016
The brain is an important modulator of glucose metabolism, and is known to respond Gastrodia elata Blume water extract (GEB). Therefore, we examined whether long-term administration of GEB has hypoglycemic activity, and its action mechanism was explored in partially-pancreatectomized rats that exhibit similar characteristics as Asian type 2 diabetes, non-obese insulin-insufficient diabetes. The rats were provided high-fat diets supplemented with either of (1) 0.5% GEB (GEB-L), (2) 2% GEB (GEB-H), (3) 2% dextrin (control), or (4) 2% dextrin with rosiglitazone (20 mg/kg body weight; positive-control) for eight weeks. GEB dose-dependently improved hypothalamic insulin signaling, enhanced whole-body insulin sensitivity during hyperinsulinemic euglycemic clamp, and reduced hepatic glucose output in a hyperinsulinemic state. GEB dose-dependently increased the area under the curve of the serum insulin levels at the first and second phases during hyperglycemic clamp compared to the control, whereas the positive control had no effect. Insulin sensitivity during the hyperglycemic state also improved, dose-dependently, in response to GEB compared with that of the control, but was less than the positive control. GEB-H increased the mass of β-cells by potentiating proliferation and decreasing apoptosis. In conclusion, GEB could be a therapeutic agent for treating Asian type 2 diabetes. View Full-Text
Keywords: Gastrodia elata Blume; insulin secretagogues; β-cell mass; insulin resistance; type 2 diabetes Gastrodia elata Blume; insulin secretagogues; β-cell mass; insulin resistance; type 2 diabetes
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Yang, H.J.; Kim, M.J.; Kwon, D.Y.; Kim, D.S.; Lee, Y.H.; Kim, J.E.; Park, S. Anti-Diabetic Activities of Gastrodia elata Blume Water Extracts Are Mediated Mainly by Potentiating Glucose-Stimulated Insulin Secretion and Increasing β-Cell Mass in Non-Obese Type 2 Diabetic Animals. Nutrients 2016, 8, 161.

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