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Selenium and Metabolic Disorders: An Emphasis on Type 2 Diabetes Risk

Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo St., Honolulu, HI 96813, USA
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Nutrients 2016, 8(2), 80; https://doi.org/10.3390/nu8020080
Received: 31 December 2015 / Accepted: 2 February 2016 / Published: 6 February 2016
(This article belongs to the Special Issue Diet and Metabolic Dysfunction)
Selenium (Se) is a micronutrient that maintains biological functions through the action of Se containing proteins known as selenoproteins. Due to the known antioxidant effects of Se, supplements containing Se have been on the rise. While Se supplementation may be beneficial for Se deficient populations, few are at risk for Se deficiency due to the transportation of food from Se-rich regions and the rise of Se-enriched foods. Alarmingly, Se supplementation may have adverse effects in people who already receive an adequate Se supply. Specifically, an increased risk of type 2 diabetes has been reported in individuals with high baseline Se levels. However, this effect was restricted to males, suggesting the relationship between Se and glucose homeostasis may be sexually dimorphic. This review will discuss the current understanding of the interaction between Se and glucose homeostasis, including any sex differences that have been described. View Full-Text
Keywords: selenium; selenoproteins; metabolic disease; trace element selenium; selenoproteins; metabolic disease; trace element
MDPI and ACS Style

Ogawa-Wong, A.N.; Berry, M.J.; Seale, L.A. Selenium and Metabolic Disorders: An Emphasis on Type 2 Diabetes Risk. Nutrients 2016, 8, 80.

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