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Supplementation with Guanidinoacetic Acid in Women with Chronic Fatigue Syndrome

Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad 21000, Serbia
School of Medicine, University of Belgrade, Belgrade 11000, Serbia
Department of Educational and Human Sciences, Burnett School of Biomedical Sciences, University of Central Florida, Orlando 32816, FL, USA
Faculty of Kinesiology, University of Split, Split 21000, Croatia
Department of Health Care Studies, University of Split, Split 21000, Croatia
Author to whom correspondence should be addressed.
Nutrients 2016, 8(2), 72;
Received: 23 November 2015 / Revised: 31 December 2015 / Accepted: 15 January 2016 / Published: 29 January 2016
A variety of dietary interventions has been used in the management of chronic fatigue syndrome (CFS), yet no therapeutic modality has demonstrated conclusive positive results in terms of effectiveness. The main aim of this study was to evaluate the effects of orally administered guanidinoacetic acid (GAA) on multidimensional fatigue inventory (MFI), musculoskeletal soreness, health-related quality of life, exercise performance, screening laboratory studies, and the occurrence of adverse events in women with CFS. Twenty-one women (age 39.3 ± 8.8 years, weight 62.8 ± 8.5 kg, height 169.5 ± 5.8 cm) who fulfilled the 1994 Centers for Disease Control and Prevention criteria for CFS were randomized in a double-blind, cross-over design, from 1 September 2014 through 31 May 2015, to receive either GAA (2.4 grams per day) or placebo (cellulose) by oral administration for three months, with a two-month wash-out period. No effects of intervention were found for the primary efficacy outcome (MFI score for general fatigue), and musculoskeletal pain at rest and during activity. After three months of intervention, participants receiving GAA significantly increased muscular creatine levels compared with the placebo group (36.3% vs. 2.4%; p < 0.01). Furthermore, changes from baseline in muscular strength and aerobic power were significantly greater in the GAA group compared with placebo (p < 0.05). Results from this study indicated that supplemental GAA can positively affect creatine metabolism and work capacity in women with CFS, yet GAA had no effect on main clinical outcomes, such as general fatigue and musculoskeletal soreness. View Full-Text
Keywords: cellular bioenergetics; creatine; general fatigue; exercise performance cellular bioenergetics; creatine; general fatigue; exercise performance
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Ostojic, S.M.; Stojanovic, M.; Drid, P.; Hoffman, J.R.; Sekulic, D.; Zenic, N. Supplementation with Guanidinoacetic Acid in Women with Chronic Fatigue Syndrome. Nutrients 2016, 8, 72.

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