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Open AccessArticle

Impact of Proteins on the Uptake, Distribution, and Excretion of Phenolics in the Human Body

Unilever R&D Vlaardingen, Olivier van Noortlaan 120, Vlaardingen 3133 AT, The Netherlands
Eurofins Spinnovation Analytical, Oss 5342 CC, The Netherlands
Eurofins Global Central Laboratory, Breda 4817 PA, The Netherlands
Author to whom correspondence should be addressed.
Nutrients 2016, 8(12), 814;
Received: 4 November 2016 / Revised: 6 December 2016 / Accepted: 8 December 2016 / Published: 15 December 2016
(This article belongs to the Special Issue Antioxidants in Health and Disease)
Polyphenols, a complex group of secondary plant metabolites, including flavonoids and phenolic acids, have been studied in depth for their health-related benefits. The activity of polyphenols may, however, be hampered when consumed together with protein-rich food products, due to the interaction between polyphenols and proteins. To that end we have tested the bioavailability of representatives of a range of polyphenol classes when consumed for five days in different beverage matrices. In a placebo-controlled, randomized, cross-over study, 35 healthy males received either six placebo gelatine capsules consumed with 200 mL of water, six capsules with 800 mg polyphenols derived from red wine and grape extracts, or the same dose of polyphenols incorporated into 200 mL of either pasteurized dairy drink, soy drink (both containing 3.4% proteins) or fruit-flavoured protein-free drink . At the end of the intervention urine and blood was collected and analysed for a broad range of phenolic compounds using Gas Chromatography–Mass Spectrometry (GC-MS), Liquid Chromatography–Multiple Reaction Monitoring–Mass Spectrometry (LC-MRM-MS), and Nuclear Magnetic Resonance (NMR) spectroscopy techniques. The plasma and urine concentrations of the polyphenols identified increased with all formats, including the protein-rich beverages. Compared to capsule ingestion, consumption of polyphenol-rich beverages containing either dairy, soy or no proteins had minor to no effect on the bioavailability and excretion of phenolic compounds in plasma (118% ± 9%) and urine (98% ± 2%). We conclude that intake of polyphenols incorporated in protein-rich drinks does not have a major impact on the bioavailability of a range of different polyphenols and phenolic metabolites. View Full-Text
Keywords: bioavailability; flavonoids; catechins; protein; resveratrol; valerolactones bioavailability; flavonoids; catechins; protein; resveratrol; valerolactones
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Draijer, R.; Van Dorsten, F.A.; Zebregs, Y.E.; Hollebrands, B.; Peters, S.; Duchateau, G.S.; Grün, C.H. Impact of Proteins on the Uptake, Distribution, and Excretion of Phenolics in the Human Body. Nutrients 2016, 8, 814.

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