Nutrients 2016, 8(11), 696; https://doi.org/10.3390/nu8110696
The Effect of Serum 25-Hydroxyvitamin D Concentrations on Elevated Serum C-Reactive Protein Concentrations in Normal Weight, Overweight and Obese Participants of a Preventive Health Program
Silmara S. B. S. Mastroeni 1,2, Lalani L. Munasinghe 2, Truong-Minh Pham 2, Sarah A. Loehr 2, John Paul Ekwaru 2, Marco F. Mastroeni 2,3
and Paul J. Veugelers 2,*
and Paul J. Veugelers 2,*
1
Department of Physical Education, University of Joinville Region, Rua Paulo Malschitzki, No. 10, Joinville 89.219-710, Brazil
2
Population Health Intervention Research Unit, School of Public Health, University of Alberta, 3-50 University Terrace, 8303-112 St., Edmonton, AB T6G 2T4, Canada
3
Post-graduation Program in Health and Environment, University of Joinville Region, Rua Paulo Malschitzki, No. 10, Joinville 89.219-710, Brazil
*
Author to whom correspondence should be addressed.
Received: 23 August 2016 / Revised: 27 October 2016 / Accepted: 1 November 2016 / Published: 4 November 2016
(This article belongs to the Special Issue Vitamin D: Current Issues and New Perspectives)
Abstract
The hypothesized effect of vitamin D on C-reactive protein (CRP) has received substantial attention as a potential means to alleviate the risk for cardiovascular disease. However, observational studies have been inconsistent in their reporting of associations between serum 25-hydroxyvitamin D (25(OH)D) and CRP concentrations, and trials and meta analyses have been inconsistent in their conclusions regarding the effect of vitamin D supplementation on CRP concentrations. These supplementation trials were mostly conducted among patients with more or less inflammatory complications and did not consider potential distinctive effects by weight status. To further our understanding of the potential influences of vitamin D on CRP, we analyzed longitudinal observations of 6755 participants of a preventative health program. On average, serum 25(OH)D concentrations increased from 88.3 to 121.0 nmol/L and those of CRP decreased from 1.7 to 1.6 mg/L between baseline and follow up. Relative to obese participants without temporal increases in 25(OH)D, those who showed improvements of <25, 25–50, 50–75, and more than 75 nmol/L at follow up were 0.57 (95% confidence interval: 0.37–0.88), 0.54 (0.34–0.85), 0.49 (0.30–0.80), and 0.48 (0.29–0.78) times as likely to have elevated CRP concentrations (≥1 mg/L), respectively. These associations were less pronounced and not statistically significant for normal weight and overweight participants. Herewith, the findings suggest that promotion of adequate serum 25(OH)D concentrations among obese individuals along with healthy lifestyles may alleviate the public health burden associated with cardiovascular disease. View Full-TextKeywords:
serum 25-hydroxyvitamin D; vitamin D; C-reactive protein; inflammation; obesity; cardiovascular disease
▼
Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Share & Cite This Article
MDPI and ACS Style
Mastroeni, S.S.B.S.; Munasinghe, L.L.; Pham, T.-M.; Loehr, S.A.; Ekwaru, J.P.; Mastroeni, M.F.; Veugelers, P.J. The Effect of Serum 25-Hydroxyvitamin D Concentrations on Elevated Serum C-Reactive Protein Concentrations in Normal Weight, Overweight and Obese Participants of a Preventive Health Program. Nutrients 2016, 8, 696.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Related Articles
Article Metrics
Comments
[Return to top]
Nutrients
EISSN 2072-6643
Published by MDPI AG, Basel, Switzerland
RSS
E-Mail Table of Contents Alert