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Open AccessArticle

The Association between the Lipids Levels in Blood and Risk of Age-Related Macular Degeneration

by 1,2,3,†, 3,†, 4, 3, 5, 6,*, 1,* and 2,3,7,*
The First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, Xi’an 710061, China
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China
School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710049, China
Department of Public Health, Xi’an Medical University, Xi’an 710021, China
School of Humanities, Xi’an Jiaotong University, Xi’an 710049, China
Xi’an Honghui Hospital, Xi’an 710054, China
Key Laboratory of Environment and Genes Related to Diseases (Xi’an Jiaotong University), Ministry of Education of China, Xi’an 710049, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2016, 8(10), 663;
Received: 6 August 2016 / Revised: 3 October 2016 / Accepted: 17 October 2016 / Published: 22 October 2016
Lipid metabolism may be involved in the pathogenic mechanism of age-related macular degeneration (AMD). However, conflicting results have been reported in the associations of AMD with blood lipids. We performed a meta-analysis including a total of 19 studies to evaluate associations between blood lipids and this disease. The result reported that the high level of high-density lipoprotein cholesterol (HDL-C) obtained with an increment of 1 mmol/L could result in a significantly increase in the AMD risk of approximately 18% (relative risk (RR), 1.18; 95% confidence interval (CI), 1.01 to 1.35; I2 = 53.8%; p = 0.007). High levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) were significantly associated with a decreased risk of AMD (RRs ranging from 0.92 to 0.95; all p < 0.05). The stratified analysis based on AMD subtypes showed that these blood lipids were only significantly associated with the risk of early AMD (all p < 0.05). The association between the blood lipids and AMD risk did not differ substantially based on the other characteristics of the participants. A high HDL-C level was associated with an increased AMD risk, whereas participants with high TC, LDL-C, and TG concentrations may show a decreased risk for this disease. Further well-designed large studies are warranted to confirm the conclusions. View Full-Text
Keywords: age-related macular degeneration; blood lipids levels; HDL; meta-analysis age-related macular degeneration; blood lipids levels; HDL; meta-analysis
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Wang, Y.; Wang, M.; Zhang, X.; Zhang, Q.; Nie, J.; Zhang, M.; Liu, X.; Ma, L. The Association between the Lipids Levels in Blood and Risk of Age-Related Macular Degeneration. Nutrients 2016, 8, 663.

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