Next Article in Journal
Probiotic Soy Product Supplemented with Isoflavones Improves the Lipid Profile of Moderately Hypercholesterolemic Men: A Randomized Controlled Trial
Next Article in Special Issue
Dietary Natural Products for Prevention and Treatment of Liver Cancer
Previous Article in Journal
Stability of Vitamin A, Iron and Zinc in Fortified Rice during Storage and Its Impact on Future National Standards and Programs—Case Study in Cambodia
Previous Article in Special Issue
Systematic Review of Anthocyanins and Markers of Cardiovascular Disease
Article Menu

Export Article

Correction published on 19 February 2016, see Nutrients 2016, 8(2), 105.

Open AccessArticle
Nutrients 2016, 8(1), 48;

Cancer Prevention and Health Benefices of Traditionally Consumed Borago officinalis Plants

Department of Plant Breeding, Institute of Sustainable Agriculture, CSIC, Av. Menéndez Pidal s/n, Córdoba E-14004, Spain
Department of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Department of Genetics, Gregor Mendel Building, Faculty of Science, University of Córdoba, Campus Rabanales, Córdoba 14014, Spain
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 19 November 2015 / Revised: 28 December 2015 / Accepted: 11 January 2016 / Published: 18 January 2016
(This article belongs to the Special Issue Health-Promoting Components of Fruits and Vegetables in Human Health)
Full-Text   |   PDF [1322 KB, uploaded 18 January 2016]   |  


Nowadays, healthy eating is increasing the demand of functional foods by societies as sources of bioactive products with healthy qualities. For this reason, we tested the safety of the consumption of Borago officinalis L. and its main phenolic components as well as the possibility of its use as a nutraceutical plant to help in cancer prevention. The in vivo Drosophila Somatic Mutation and Recombination Test (SMART) and in vitro HL-60 human cell systems were performed, as well-recognized methods for testing genotoxicity/cytotoxicity of bioactive compounds and plant products. B. officinalis and the tested compounds possess antigenotoxic activity. Moreover, B. officinalis wild type cultivar exerts the most antigenotoxic values. Cytotoxic effect was probed for both cultivars with IC50 values of 0.49 and 0.28 mg·mL−1 for wild type and cultivated plants respectively, as well as their constituent rosmarinic acid and the assayed phenolic mixture (IC50 = 0.07 and 0.04 mM respectively). B. officinalis exerts DNA protection and anticarcinogenic effects as do its component rosmarinic acid and the mixture of the main phenolics presented in the plant. In conclusion, the results showed that B. officinalis may represent a high value plant for pleiotropic uses and support its consumption as a nutraceutical plant. View Full-Text
Keywords: Borago officinalis; health; safety; dietary bioactives; vegetables; SMART; HL-60; cancer prevention Borago officinalis; health; safety; dietary bioactives; vegetables; SMART; HL-60; cancer prevention

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Lozano-Baena, M.-D.; Tasset, I.; Muñoz-Serrano, A.; Alonso-Moraga, Á.; de Haro-Bailón, A. Cancer Prevention and Health Benefices of Traditionally Consumed Borago officinalis Plants. Nutrients 2016, 8, 48.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top