Dietary Vitamin K Intake Is Associated with Cognition and Behaviour among Geriatric Patients: The CLIP Study
by
Justine Chouet 1, Guylaine Ferland 2, Catherine Féart 3,4, Yves Rolland 5, Nancy Presse 2, Kariane Boucher 2, Pascale Barberger-Gateau 3,4, Olivier Beauchet 1 and Cedric Annweiler 1,6,*
Justine Chouet 1, Guylaine Ferland 2, Catherine Féart 3,4, Yves Rolland 5, Nancy Presse 2, Kariane Boucher 2, Pascale Barberger-Gateau 3,4, Olivier Beauchet 1 and Cedric Annweiler 1,6,*
1
Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, Angers University Memory Clinic; UPRES EA 4638, University of Angers, UNAM, Angers F-49933, France
2
Centre de recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, QC H3W 1W5, Canada
3
Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux F-33000, France
4
INSERM, ISPED, INSERM_U897-Epidemiologie-Biostatistique, Bordeaux F-33000, France
5
Department of Geriatric Medicine, Institut du Vieillissement, University Hospital, INSERM U1027, Toulouse F-31400, France
6
Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON N6A 5B7, Canada
*
Author to whom correspondence should be addressed.
Nutrients 2015, 7(8), 6739-6750; https://doi.org/10.3390/nu7085306
Received: 15 June 2015 / Revised: 16 July 2015 / Accepted: 24 July 2015 / Published: 12 August 2015
(This article belongs to the Special Issue Vitamin K and Vitamin K-Dependent Proteins in Relation to Human Health)
Our objective was to determine whether dietary vitamin K intake was associated with cognition and behavior among older adults. 192 consecutive participants ≥65 years, recruited in the cross-sectional CLIP (Cognition and LIPophilic vitamins) study, were separated into two groups according to the tertiles of dietary phylloquinone intake (i.e., lowest third below 207 µg/day versus the other two thirds combined). Daily dietary phylloquinone intake was estimated from 50-item interviewer-administered food frequency questionnaire. Cognition was assessed with Mini-Mental State Examination (MMSE); behaviour with Frontotemporal Behavioral Rating Scale (FBRS). Age, gender, social problems, education, body mass index (BMI), comorbidities, history of stroke, use vitamin K antagonists, inadequate fatty fish intake, serum thyroid-stimulating hormone (TSH), vitamin B12, albumin, and estimated glomerular filtration rate were used as confounders. Compared to participants in the lowest third of dietary phylloquinone intake (n = 64), those with higher intake had higher (i.e., better) mean MMSE score (22.0 ± 5.7 versus 19.9 ± 6.2, p = 0.024) and lower (i.e., better) FBRS score (1.5 ± 1.2 versus 1.9 ± 1.3, p = 0.042). In multivariate linear regressions, log dietary phylloquinone intake was positively associated with MMSE score (adjusted β = 1.66, p = 0.013) and inversely associated with FBRS score (adjusted β = −0.33, p = 0.037). Specifically, log dietary phylloquinone intake correlated negatively with FBRS subscore of physical neglect (r = −0.24, p = 0.001). Higher dietary phylloquinone intake was associated with better cognition and behavior among older adults.
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Keywords:
cognition; behavior; diet; older adults; vitamin K
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MDPI and ACS Style
Chouet, J.; Ferland, G.; Féart, C.; Rolland, Y.; Presse, N.; Boucher, K.; Barberger-Gateau, P.; Beauchet, O.; Annweiler, C. Dietary Vitamin K Intake Is Associated with Cognition and Behaviour among Geriatric Patients: The CLIP Study. Nutrients 2015, 7, 6739-6750.
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