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Open AccessArticle

Postprandial Responses to Lipid and Carbohydrate Ingestion in Repeated Subcutaneous Adipose Tissue Biopsies in Healthy Adults

1
School of Exercise & Nutrition Sciences, Deakin University, Victoria 3125, Australia
2
Department of Nutrition & Dietetics, Monash University, Victoria 3168, Australia
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School of Biological Sciences, University of Auckland, Auckland 1142, New Zealand
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Basic and Clinical Myology Laboratory, Department of Physiology, University of Melbourne, Victoria 3010, Australia
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Department of Physiology, Anatomy and Microbiology, College of Science, Health and Engineering, LaTrobe University, Victoria 3086, Australia
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Metabolic Research Unit, Deakin University, Waurn Ponds, Victoria 3216, Australia
7
Liggins Institute, University of Auckland, Auckland 1142, New Zealand
*
Author to whom correspondence should be addressed.
Nutrients 2015, 7(7), 5347-5361; https://doi.org/10.3390/nu7075224
Received: 3 June 2015 / Revised: 24 June 2015 / Accepted: 24 June 2015 / Published: 1 July 2015
Adipose tissue is a primary site of meta-inflammation. Diet composition influences adipose tissue metabolism and a single meal can drive an inflammatory response in postprandial period. This study aimed to examine the effect lipid and carbohydrate ingestion compared with a non-caloric placebo on adipose tissue response. Thirty-three healthy adults (age 24.5 ± 3.3 year (mean ± standard deviation (SD)); body mass index (BMI) 24.1 ± 3.2 kg/m2, were randomised into one of three parallel beverage groups; placebo (water), carbohydrate (maltodextrin) or lipid (dairy-cream). Subcutaneous, abdominal adipose tissue biopsies and serum samples were collected prior to (0 h), as well as 2 h and 4 h after consumption of the beverage. Adipose tissue gene expression levels of monocyte chemoattractant protein-1 (MCP-1), interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) increased in all three groups, without an increase in circulating TNF-α. Serum leptin (0.6-fold, p = 0.03) and adipose tissue leptin gene expression levels (0.6-fold, p = 0.001) decreased in the hours following the placebo beverage, but not the nutrient beverages. Despite increased inflammatory cytokine gene expression in adipose tissue with all beverages, suggesting a confounding effect of the repeated biopsy method, differences in metabolic responses of adipose tissue and circulating adipokines to ingestion of lipid and carbohydrate beverages were observed. View Full-Text
Keywords: adipokine; adipose tissue; biopsy; inflammation; postprandial adipokine; adipose tissue; biopsy; inflammation; postprandial
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Dordevic, A.L.; Pendergast, F.J.; Morgan, H.; Villas-Boas, S.; Caldow, M.K.; Larsen, A.E.; Sinclair, A.J.; Cameron-Smith, D. Postprandial Responses to Lipid and Carbohydrate Ingestion in Repeated Subcutaneous Adipose Tissue Biopsies in Healthy Adults. Nutrients 2015, 7, 5347-5361.

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