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Mechanistic Effects of Calcitriol in Cancer Biology

Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15, Tlalpan, Mexico City 14000, Mexico
Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, Blvd. Juriquilla 3001, Querétaro 76230, Mexico
Author to whom correspondence should be addressed.
Nutrients 2015, 7(6), 5020-5050;
Received: 3 May 2015 / Revised: 9 June 2015 / Accepted: 12 June 2015 / Published: 19 June 2015
Besides its classical biological effects on calcium and phosphorus homeostasis, calcitriol, the active vitamin D metabolite, has a broad variety of actions including anticancer effects that are mediated either transcriptionally and/or via non-genomic pathways. In the context of cancer, calcitriol regulates the cell cycle, induces apoptosis, promotes cell differentiation and acts as anti-inflammatory factor within the tumor microenvironment. In this review, we address the different mechanisms of action involved in the antineoplastic effects of calcitriol. View Full-Text
Keywords: calcitriol; cancer; inflammation; vitamin D deficiency; oncogenesis calcitriol; cancer; inflammation; vitamin D deficiency; oncogenesis
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Díaz, L.; Díaz-Muñoz, M.; García-Gaytán, A.C.; Méndez, I. Mechanistic Effects of Calcitriol in Cancer Biology. Nutrients 2015, 7, 5020-5050.

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