Next Article in Journal
The Contribution of Fortified Ready-to-Eat Cereal to Vitamin and Mineral Intake in the U.S. Population, NHANES 2007–2010
Next Article in Special Issue
Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review
Previous Article in Journal
Reviewing the Effects of l-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis
Previous Article in Special Issue
Selenium and Chronic Diseases: A Nutritional Genomics Perspective
Open AccessReview

The Subcellular Location of Selenoproteins and the Impact on Their Function

Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USA
Nutrients 2015, 7(5), 3938-3948;
Received: 8 April 2015 / Revised: 14 May 2015 / Accepted: 15 May 2015 / Published: 22 May 2015
(This article belongs to the Special Issue Dietary Selenium and Human Health)
Most human selenium containing proteins contain selenium in the form of the amino acid selenocysteine, which is encoded in the corresponding mRNA as a UGA codon. Only a few non-selenocysteine containing selenoproteins are present and the nature of the association with selenium is not well understood. This review focuses on two selenocysteine-containing proteins that are members of the glutathione peroxidase family, GPx-1 and GPx-4, and the selenium-associated protein referred to as Selenium Binding Protein 1. Each of these proteins have been described to reside in two or more cellular compartments, and in the case of GPx-1 and SBP1, interact with each other. The enzymatic activity of GPx-1 and GPx-4 have been well described, but it is less clear how their cellular location impacts the health related phenotypes associated with activities, while no catalytic function is assigned to SBP1. The distribution of these proteins is presented as is the possible consequences of that compartmentalization. View Full-Text
Keywords: selenium; selenoproteins; peroxidases; compartmentalization; cancer selenium; selenoproteins; peroxidases; compartmentalization; cancer
Show Figures

Figure 1

MDPI and ACS Style

Diamond, A.M. The Subcellular Location of Selenoproteins and the Impact on Their Function. Nutrients 2015, 7, 3938-3948.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop