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Open AccessArticle

Improved Blood Biomarkers but No Cognitive Effects from 16 Weeks of Multivitamin Supplementation in Healthy Older Adults

1
Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia
2
Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, VIC 3125, Australia
*
Author to whom correspondence should be addressed.
Nutrients 2015, 7(5), 3796-3812; https://doi.org/10.3390/nu7053796
Received: 30 March 2015 / Revised: 11 May 2015 / Accepted: 13 May 2015 / Published: 19 May 2015
(This article belongs to the Special Issue Nutrition in Cognitive Function)
Supplementation with vitamins, minerals and phytonutrients may be beneficial for cognition, especially in older adults. The aim of this study was to assess the effects of multivitamin supplementation in older adults on cognitive function and associated blood biomarkers. In a randomised, double blind, placebo-controlled trial, healthy women (n = 68) and men (n = 48) aged 55–65 years were supplemented daily for 16 weeks with women’s and men’s formula multivitamin supplements. Assessments at baseline and post-supplementation included computerised cognitive tasks and blood biomarkers relevant to cognitive aging. No cognitive improvements were observed after supplementation with either formula; however, several significant improvements were observed in blood biomarkers including increased levels of vitamins B6 and B12 in women and men; reduced C-reactive protein in women; reduced homocysteine and marginally reduced oxidative stress in men; as well as improvements to the lipid profile in men. In healthy older people, multivitamin supplementation improved a number of blood biomarkers that are relevant to cognition, but these biomarker changes were not accompanied by improved cognitive function. View Full-Text
Keywords: multivitamins; vitamins; cognition; biomarkers multivitamins; vitamins; cognition; biomarkers
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Harris, E.; Macpherson, H.; Pipingas, A. Improved Blood Biomarkers but No Cognitive Effects from 16 Weeks of Multivitamin Supplementation in Healthy Older Adults. Nutrients 2015, 7, 3796-3812.

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