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The Role of Omega-3 Fatty Acids in Acute Pancreatitis: A Meta-Analysis of Randomized Controlled Trials

1
Graduate School, Southern Medical University, Guangzhou 510515, China
2
Department of General Surgery, Jinling Hospital, Clinical College of Southern Medical University, Nanjing 210002, China
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Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China
4
Department of Surgery, Prince of Wales Hospital, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong 999077, China
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Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical College, Dongguan 523808, China
*
Author to whom correspondence should be addressed.
Nutrients 2015, 7(4), 2261-2273; https://doi.org/10.3390/nu7042261
Received: 24 December 2014 / Revised: 23 February 2015 / Accepted: 17 March 2015 / Published: 31 March 2015
To determine whether treatment with omega-3 fatty acids (ω-3 FA) provides benefits to patients with acute pancreatitis (AP). The Cochrane Library, PubMed, Embase, Web of Science, and Chinese Biomedical Literature Database were searched. Data analysis was performed using Revman 5.2 software. A total of eight randomized controlled trials (RCTs) were included. Overall, ω-3 FA treatment resulted in a significantly reduced risk of mortality (RR 0.35; 95% CI 0.16 to 0.75, p < 0.05), infectious complications (RR 0.54; 95% CI 0.34 to 0.85, p < 0.05) and length of hospital stay (MD –6.50; 95% CI −9.54 to −3.46, p < 0.05), but not length of ICU stay (MD −1.98; 95% CI −6.92 to 2.96, p > 0.05). In subgroup analysis, only patients who received ω-3 FA parenterally had some statistically significant benefits in terms of mortality (risk ratio (RR) 0.37; 95% confidence interval (CI) 0.16 to 0.86, p < 0.05), infectious complications (RR 0.5; 95% CI 0.28 to 0.9, p < 0.05) and length of hospital stay (mean difference (MD) −8.13; 95% CI −10.39 to −5.87, p < 0.001). The administration of ω-3 FA may be beneficial for decreasing mortality, infectious complications, and length of hospital stay in AP, especially when used parenterally. Large and rigorously designed RCTs are required to elucidate the efficacy of parenteral or enteral ω-3 FA treatment in AP. View Full-Text
Keywords: acute pancreatitis; omega-3 fatty acids; nutrition support; parenteral nutrition; enteral nutrition; meta-analysis acute pancreatitis; omega-3 fatty acids; nutrition support; parenteral nutrition; enteral nutrition; meta-analysis
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MDPI and ACS Style

Lei, Q.C.; Wang, X.Y.; Xia, X.F.; Zheng, H.Z.; Bi, J.C.; Tian, F.; Li, N. The Role of Omega-3 Fatty Acids in Acute Pancreatitis: A Meta-Analysis of Randomized Controlled Trials. Nutrients 2015, 7, 2261-2273. https://doi.org/10.3390/nu7042261

AMA Style

Lei QC, Wang XY, Xia XF, Zheng HZ, Bi JC, Tian F, Li N. The Role of Omega-3 Fatty Acids in Acute Pancreatitis: A Meta-Analysis of Randomized Controlled Trials. Nutrients. 2015; 7(4):2261-2273. https://doi.org/10.3390/nu7042261

Chicago/Turabian Style

Lei, Qiu C.; Wang, Xin Y.; Xia, Xian F.; Zheng, Hua Z.; Bi, Jing C.; Tian, Feng; Li, Ning. 2015. "The Role of Omega-3 Fatty Acids in Acute Pancreatitis: A Meta-Analysis of Randomized Controlled Trials" Nutrients 7, no. 4: 2261-2273. https://doi.org/10.3390/nu7042261

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