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The Positive Effects of Yerba Maté (Ilex paraguariensis) in Obesity

Laboratory of Microbiology and Molecular Biology, Clinical Pharmacology and Gastroenterology Unit, Sao Francisco University Medical School, Av São Francisco de Assis 218, Bragança Paulista, SP 12916-900, Brazil
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Nutrients 2015, 7(2), 730-750; https://doi.org/10.3390/nu7020730
Received: 26 May 2014 / Accepted: 6 January 2015 / Published: 22 January 2015
(This article belongs to the Special Issue Nutrient: Gene Interactions)
The prevalence of obesity has increased worldwide over the past three decades. Global anti-obesity strategies focus on dietary and lifestyle modifications to slow the development of obesity. Research in the nutrition field has recently aroused considerable interest based on the potential of natural products to counteract obesity. Several studies have identified yerba maté (Ilex paraguariensis) as an excellent candidate. In this review, we evaluated the impact of yerba maté on obesity and obesity-related inflammation. Cellular studies demonstrate that yerba maté suppresses adipocyte differentiation and triglyceride accumulation and reduces inflammation. Animal studies show that yerba maté modulates signaling pathways that regulate adipogenesis, antioxidant, anti-inflammatory and insulin signaling responses. In summary, the data presented here showed that the use of yerba maté might be useful against obesity, improving the lipid parameters in humans and animal models. In addition, yerba maté modulates the expression of genes that are changed in the obese state and restores them to more normal levels of expression. In doing so, it addresses several of the abnormal and disease-causing factors associated with obesity. Protective and ameliorative effects on insulin resistance were also observed. Thus, as a general conclusion, it seems that yerba maté beverages and supplements might be helpful in the battle against obesity. View Full-Text
Keywords: yerba maté; Ilex paraguariensis; obesity; adipogenesis; inflammation yerba maté; Ilex paraguariensis; obesity; adipogenesis; inflammation
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Gambero, A.; Ribeiro, M.L. The Positive Effects of Yerba Maté (Ilex paraguariensis) in Obesity. Nutrients 2015, 7, 730-750.

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