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Open AccessArticle

Association of Proton Pump Inhibitor (PPI) Use with Energy Intake, Physical Activity, and Weight Gain

Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus 12631 E. 17th Ave., Room 7619, Aurora, CO 80045, USA
Author to whom correspondence should be addressed.
Nutrients 2015, 7(10), 8592-8601;
Received: 24 July 2015 / Revised: 28 September 2015 / Accepted: 30 September 2015 / Published: 19 October 2015
Studies suggest proton pump inhibitor (PPI) use impacts body weight regulation, though the effect of PPIs on energy intake, energy extraction, and energy expenditure is unknown. We used data on 3073 eligible adults from the National Health and Nutrition Examination Survey (NHANES). Medication use, energy intake, diet composition, and physical activity were extracted from NHANES. Multivariate regression models included confounding variables. Daily energy intake was similar between PPI users and non-users (p = 0.41). Diet composition was similar between the two groups, except that PPI users consumed a slightly greater proportion of calories from fat (34.5% vs. 33.2%; p = 0.02). PPI users rated themselves as being as physically active as their age/gender-matched peers and reported similar frequencies of walking or biking. However, PPI users were less likely to have participated in muscle-strengthening activities (OR: 0.53; 95% CI: 0.30–0.95). PPI users reported similar sedentary behaviors to non-users. Male PPI users had an increase in weight (of 1.52 ± 0.59 kg; p = 0.021) over the previous year compared to non-users, while female PPI users had a non-significant increase in weight. The potential mechanisms for PPI-associated weight gain are unclear as we did not find evidence for significant differences in energy intake or markers of energy expenditure. View Full-Text
Keywords: proton pump inhibitor; weight; energy intake; physical activity proton pump inhibitor; weight; energy intake; physical activity
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Czwornog, J.L.; Austin, G.L. Association of Proton Pump Inhibitor (PPI) Use with Energy Intake, Physical Activity, and Weight Gain. Nutrients 2015, 7, 8592-8601.

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