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Open AccessReview

Nutritionally-Induced Catch-Up Growth

The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Children's Diabetes, Schneider Children's Medical Center of Israel, and Felsenstein Medical Research Center, Petach Tikva 49100, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel
Author to whom correspondence should be addressed.
Nutrients 2015, 7(1), 517-551;
Received: 9 October 2014 / Accepted: 31 December 2014 / Published: 14 January 2015
(This article belongs to the Special Issue Nutrition and Bone Health)
Malnutrition is considered a leading cause of growth attenuation in children. When food is replenished, spontaneous catch-up (CU) growth usually occurs, bringing the child back to its original growth trajectory. However, in some cases, the CU growth is not complete, leading to a permanent growth deficit. This review summarizes our current knowledge regarding the mechanism regulating nutrition and growth, including systemic factors, such as insulin, growth hormone, insulin- like growth factor-1, vitamin D, fibroblast growth factor-21, etc., and local mechanisms, including autophagy, as well as regulators of transcription, protein synthesis, miRNAs and epigenetics. Studying the molecular mechanisms regulating CU growth may lead to the establishment of better nutritional and therapeutic regimens for more effective CU growth in children with malnutrition and growth abnormalities. It will be fascinating to follow this research in the coming years and to translate the knowledge gained to clinical benefit. View Full-Text
Keywords: growth; growth plate; nutrition; catch-up growth growth; growth plate; nutrition; catch-up growth
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Gat-Yablonski, G.; Phillip, M. Nutritionally-Induced Catch-Up Growth. Nutrients 2015, 7, 517-551.

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