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Open AccessArticle

Zinc Fortification Decreases ZIP1 Gene Expression of Some Adolescent Females with Appropriate Plasma Zinc Levels

1
Research Center for Food and Development (CIAD), Km 0.6 a La Victoria, Hermosillo, Sonora 83304, Mexico
2
Technological Institute of Veracruz, UNIDA, Calzada Miguel Ángel de Quevedo 2779, Veracruz, Veracruz 91897, Mexico
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Author to whom correspondence should be addressed.
Nutrients 2014, 6(6), 2229-2239; https://doi.org/10.3390/nu6062229
Received: 4 April 2014 / Revised: 19 May 2014 / Accepted: 28 May 2014 / Published: 11 June 2014
(This article belongs to the Special Issue Nutrient Fortification and Human Health)
Zinc homeostasis is achieved after intake variation by changes in the expression levels of zinc transporters. The aim of this study was to evaluate dietary intake (by 24-h recall), absorption, plasma zinc (by absorption spectrophotometry) and the expression levels (by quantitative PCR), of the transporters ZIP1 (zinc importer) and ZnT1 (zinc exporter) in peripheral white blood cells from 24 adolescent girls before and after drinking zinc-fortified milk for 27 day. Zinc intake increased (p < 0.001) from 10.5 ± 3.9 mg/day to 17.6 ± 4.4 mg/day, and its estimated absorption from 3.1 ± 1.2 to 5.3 ± 1.3 mg/day. Mean plasma zinc concentration remained unchanged (p > 0.05) near 150 µg/dL, but increased by 31 µg/dL (p < 0.05) for 6/24 adolescents (group A) and decreased by 25 µg/dL (p < 0.05) for other 6/24 adolescents (group B). Expression of ZIP1 in blood leukocytes was reduced 1.4-fold (p < 0.006) in group A, while for the expression of ZnT1 there was no difference after intervention (p = 0.39). An increase of dietary zinc after 27-days consumption of fortified-milk did not increase (p > 0.05) the plasma level of adolescent girls but for 6/24 participants from group A in spite of the formerly appropriation, which cellular zinc uptake decreased as assessed by reduction of the expression of ZIP1. View Full-Text
Keywords: adolescent girls; zinc fortified milk; zinc intake; plasma zinc; zinc transporter expression adolescent girls; zinc fortified milk; zinc intake; plasma zinc; zinc transporter expression
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Méndez, R.O.; Santiago, A.; Yepiz-Plascencia, G.; Peregrino-Uriarte, A.B.; Barca, A.M.C.; García, H.S. Zinc Fortification Decreases ZIP1 Gene Expression of Some Adolescent Females with Appropriate Plasma Zinc Levels. Nutrients 2014, 6, 2229-2239.

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