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The Effect of Normally Consumed Amounts of Sucrose or High Fructose Corn Syrup on Lipid Profiles, Body Composition and Related Parameters in Overweight/Obese Subjects

Rippe Lifestyle Institute, 215 Celebration Place, Suite 300, Celebration, FL 34747, USA
Energy Balance Laboratory, Department of Nutrition and Food Sciences, University of Rhode Island, Kingston, RI 02881, USA
Department of Nutrition and Dietetics, University of North Florida, 1 UNF Drive, Jacksonville, FL 32256, USA
Britte Lowther, 4302 39th Street West, Apt # 11, Bradenton, FL 34015 , USA
Rippe Lifestyle Institute, 21 North Quinsigamond Avenue, Shrewsbury, MA 01545, USA
Biomedical Sciences, University of Central Florida, 4000 Central Florida Blvd Orlando, FL 32816, USA
Author to whom correspondence should be addressed.
Nutrients 2014, 6(3), 1128-1144;
Received: 9 January 2014 / Revised: 27 February 2014 / Accepted: 28 February 2014 / Published: 17 March 2014
(This article belongs to the Special Issue Sugar and Obesity)
PDF [217 KB, uploaded 17 March 2014]


The American Heart Association (AHA) has advocated that women and men not consume more than 100 and 150 kcal/day, respectively, from added sugars. These levels are currently exceeded by over 90% of the adult population in the United States. Few data exist on longer-term metabolic effects when sucrose and High Fructose Corn Syrup (HFCS), the principal sources of added dietary sugars, are consumed at levels typical of the general population. Sixty five overweight and obese individuals were placed on a eucaloric (weight stable) diet for 10-weeks, which incorporated sucrose- or HFCS-sweetened, low-fat milk at 10% or 20% of calories in a randomized, double-blinded study. All groups responded similarly (interaction p > 0.05). There was no change in body weight in any of the groups over the 10-week study, or in systolic or diastolic blood pressure. Likewise, there were no changes in total cholesterol, triglycerides, low-density lipoprotein (LDL), or apolipoprotein B (Apo B). We conclude that (1) when consumed as part of a eucaloric diet fructose—when given with glucose (as normally consumed) does not promote weight gain or an atherogenic lipid profile even when consumed at two to four times the level recently recommended by the AHA. (2) There were no differences between HFCS and sucrose on these parameters. View Full-Text
Keywords: sucrose; high fructose corn syrup; body mass sucrose; high fructose corn syrup; body mass
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lowndes, J.; Sinnett, S.; Pardo, S.; Nguyen, V.T.; Melanson, K.J.; Yu, Z.; Lowther, B.E.; Rippe, J.M. The Effect of Normally Consumed Amounts of Sucrose or High Fructose Corn Syrup on Lipid Profiles, Body Composition and Related Parameters in Overweight/Obese Subjects. Nutrients 2014, 6, 1128-1144.

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