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Insights from Space: Potential Role of Diet in the Spatial Organization of Chromosomes

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The Liggins Institute, The University of Auckland, Private Bag 92019 AMC, Auckland 1142, New Zealand
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Department of Pathology, Dunedin School of Medicine, The University of Otago, P.O. Box 913, Dunedin 9054, New Zealand
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Author to whom correspondence should be addressed.
Nutrients 2014, 6(12), 5724-5739; https://doi.org/10.3390/nu6125724
Received: 17 September 2014 / Revised: 20 November 2014 / Accepted: 21 November 2014 / Published: 10 December 2014
(This article belongs to the Special Issue Nutritional Epigenetics)
We can now sequence and identify genome wide epigenetic patterns and perform a variety of “genomic experiments” within relatively short periods of time—ranging from days to weeks. Yet, despite these technological advances, we have a poor understanding of the inter-relationships between epigenetics, genome structure-function, and nutrition. Perhaps this limitation lies, in part, in our propensity to study epigenetics in terms of the linear arrangement of elements and genes. Here we propose that a more complete understanding of how nutrition impacts on epigenetics and cellular development resides within the inter-relationships between DNA and histone modification patterns and genome function, in the context of spatial organization of chromatin and the epigenome. View Full-Text
Keywords: HiC; proximity ligation; genome organization; nutrition; epigenetics; estrogen; cohesion; CTCF HiC; proximity ligation; genome organization; nutrition; epigenetics; estrogen; cohesion; CTCF
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O'Sullivan, J.M.; Doynova, M.D.; Antony, J.; Pichlmuller, F.; Horsfield, J.A. Insights from Space: Potential Role of Diet in the Spatial Organization of Chromosomes. Nutrients 2014, 6, 5724-5739.

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