Gastric Lipase Secretion in Children with Gastritis
by
Przemyslaw J. Tomasik 1,*, Andrzej Wędrychowicz 2, Iwona Rogatko 1, Andrzej Zając 3, Krzysztof Fyderek 2 and Krystyna Sztefko 1
Przemyslaw J. Tomasik 1,*, Andrzej Wędrychowicz 2, Iwona Rogatko 1, Andrzej Zając 3, Krzysztof Fyderek 2 and Krystyna Sztefko 1
1
Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Wielicka St. 265, Krakow 30-663, Poland
2
Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, Jagiellonian University, Wielicka St. 265, Krakow 30-663, Poland
3
Department of Pediatric Surgery, Collegium Medicum, Jagiellonian University, Wielicka St. 265, Krakow 30-663, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2013, 5(8), 2924-2932; https://doi.org/10.3390/nu5082924
Received: 13 June 2013 / Revised: 28 June 2013 / Accepted: 18 July 2013 / Published: 29 July 2013
Gastric lipase is one of the prepancreatic lipases found in some mammalian species and in humans. Our knowledge of the hormonal regulation of gastric lipase secretion in children and adolescents is still very limited. The aim of this study was to compare the activity of human gastric lipase (HGL) in gastric juice in healthy adolescents and in patients with gastritis. The adolescents were allocated to three groups: the first including patients with Helicobacter pylori gastritis (HPG; n = 10), the second including patients with superficial gastritis caused by pathogens other than H. pylori (non-HPG; n = 14) and the control group including healthy adolescents (n = 14). Activity of HGL was measured in gastric juice collected during endoscopy. Plasma concentrations of cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) were measured in all adolescents. Activity of HGL in the non-HPG group was significantly lower than in the HPG group (p < 0.005) and the control group (p < 0.005). Mean plasma GIP levels in the control group were lower than in the non-HPG group (p < 0.003) and the HPG group (p < 0.01). We conclude that the regulation of HGL secretion by GLP-1 and CCK is altered in patients with gastritis. Moreover, GIP is a potent controller of HGL activity, both in healthy subjects and in patients with gastritis.
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Keywords:
CCK; gastritis; GIP; GLP-1; Helicobacter pylori; human gastric lipase; non-HP gastritis
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MDPI and ACS Style
Tomasik, P.J.; Wędrychowicz, A.; Rogatko, I.; Zając, A.; Fyderek, K.; Sztefko, K. Gastric Lipase Secretion in Children with Gastritis. Nutrients 2013, 5, 2924-2932.
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