Genome-Wide Association Study of Serum Selenium Concentrations
Abstract
:1. Introduction
2. Subjects and Methods
2.1. Study Population
2.2. Genotyping and Serum Selenium Measurement
2.3. Statistical Analysis
3. Results
Variable | PLCO ( n = 582 men) | WHI ( n = 621 women) | PLCO + WHI ( n = 1203) |
---|---|---|---|
Age (years) | 64 (5) a | 67 (7) | 65 (6) |
BMI (kg/m2) | 27.5 (3.9) | 27.8 (5.5) | 27.7 (4.8) |
Ever smoker (Yes/No) | 363 (62) b | 343 (55) | 706 (59) |
Cancer status (Yes/No) | 20 (3) | 584 (94) | 604 (50) |
Selenium levels (mg/dL) | 142.4 (27.0) | 138.1 (21.3) | 140.2 (24.3) |
SNP | Position a | Gene b | Coded allele | CAF c | PLCO | WHI | Combined analysis | |||
---|---|---|---|---|---|---|---|---|---|---|
beta | p value | beta | p value | Beta | p value | |||||
rs1506807 | 4:178554686 | AGA | A | 0.73 | −0.059 | 8.39E−06 | −0.025 | 1.32E−0 | −0.043 | 2.63E−07 |
rs1395479 | 4:178555185 | AGA | A | 0.27 | 0.059 | 8.31E−06 | 0.025 | 1.33E−02 | 0.043 | 2.62E−07 |
rs891684 | 17:68225134 | SLC39A11 | A | 0.05 | −0.133 | 8.73E−06 | −0.057 | 9.99E−03 | −0.093 | 4.04E−07 |
4. Discussion
5. Conclusions
Acknowledgements
Conflict of Interest
References
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Gong, J.; Hsu, L.; Harrison, T.; King, I.B.; Stürup, S.; Song, X.; Duggan, D.; Liu, Y.; Hutter, C.; Chanock, S.J.; et al. Genome-Wide Association Study of Serum Selenium Concentrations. Nutrients 2013, 5, 1706-1718. https://doi.org/10.3390/nu5051706
Gong J, Hsu L, Harrison T, King IB, Stürup S, Song X, Duggan D, Liu Y, Hutter C, Chanock SJ, et al. Genome-Wide Association Study of Serum Selenium Concentrations. Nutrients. 2013; 5(5):1706-1718. https://doi.org/10.3390/nu5051706
Chicago/Turabian StyleGong, Jian, Li Hsu, Tabitha Harrison, Irena B. King, Stefan Stürup, Xiaoling Song, David Duggan, Yan Liu, Carolyn Hutter, Stephen J. Chanock, and et al. 2013. "Genome-Wide Association Study of Serum Selenium Concentrations" Nutrients 5, no. 5: 1706-1718. https://doi.org/10.3390/nu5051706