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Open AccessArticle

The Blood Lactate Increase in High Intensity Exercise Is Depressed by Acanthopanax sieboldianus

Department of Health and Nutrition, Yonezawa Women's Junior College of Yamagata Prefecture, Yonezawa 992-0025, Japan
Department of Sport, Kyungil University, Gyeongsan, Gteongbuk 712-701, Korea
Department of Human Movement Science, Seoul Women's University, 621 Hwarangro, Nowon-Gu, Seoul 139-774, Korea
Author to whom correspondence should be addressed.
Nutrients 2013, 5(10), 4134-4144;
Received: 1 July 2013 / Revised: 9 September 2013 / Accepted: 23 September 2013 / Published: 16 October 2013
PDF [318 KB, uploaded 16 October 2013]


This study investigates the anti-fatigue effects of Acanthopanax sieboldianus (A. sieboldianus) at various exercise intensities. Two experiments were conducted in 18 Sprague-Dawley rats. In Experiment 1, a three-stage increment test (15 m/min for 5 min, and 20 m/min for 5 min and 25 m/min for 10 min) was performed using a treadmill. In Experiment 2, a 10-min swimming test was conducted. Blood samples were extracted from each rat before, during and after the exercises and the blood concentrations of lactate and glucose measured. In both experiments, water (control) or A. sieboldianus solution (ASS) was administered orally using a zonde 30 min before the exercise. In the swimming test, ASS administration significantly decreased the blood lactate level measured at the end of the exercise and 5 min post-exercise relative to the water group, although the two groups did not differ significantly in the treadmill test. Our study demonstrates that a single oral administration of A. sieboldianus prior to high-intensity exercise significantly decreases the blood lactate concentration suggesting that A. sieboldianus has an intrinsic anti-fatigue effect. View Full-Text
Keywords: Acanthopanax sieboldianus; running; swimming; blood lactate; fatigue Acanthopanax sieboldianus; running; swimming; blood lactate; fatigue

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Kato, M.; Kurakane, S.; Nishina, A.; Park, J.; Chang, H. The Blood Lactate Increase in High Intensity Exercise Is Depressed by Acanthopanax sieboldianus. Nutrients 2013, 5, 4134-4144.

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