Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea
1
Unit of Clinical Nutrition, Tel Aviv Sourasky Medical Center, Sackler Faulty of Medicine, Tel Aviv University, Tel Aviv, 64239, Israel
2
Pediatric Emergency Room, Soroka University Medical Center, Beer-Sheva, 84101, Israel
3
Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer-Sheva, 84111, Israel
4
Danone Research Friedrichsdorf, Germany and Sophia Children’s Hospital, Erasmus University, Rotterdam, 3015GJ, The Netherlands
5
Immunology Laboratory for Tumor Diagnosis, Oncology Department, Hadassah-Hebrew University Medical Center, Jerusalem, 91120, Israel
*
Author to whom correspondence should be addressed.
Nutrients 2010, 2(7), 683-692; https://doi.org/10.3390/nu2070683
Received: 17 May 2010 / Revised: 18 June 2010 / Accepted: 21 June 2010 / Published: 30 June 2010
(This article belongs to the Special Issue Paediatric Nutrition and Metabolism)
Abstract
We investigated the effect of a mixture of long-chain fructo-oligosaccharides, galacto-oligosaccharides and acidic oligosaccharides on the number and consistency of stools and on immune system biomarkers in 104 supplemented and non-supplemented subjects (aged 9–24 months) with acute diarrhea. Interleukin-1 (IL-1), IL-1RA, IL-6, IL-8, IL-10, TNF-α and sIL-2R cytokine levels were determined. The significant decrease in number of stools and increase in stool consistency in the supplemented group was of little clinical relevance. The only significant change in pro- and anti-inflammatory cytokines was decreased TNF-α levels in the supplemented group. Prebiotic supplementation during acute diarrhea episodes did not influence the clinical course. View Full-TextKeywords:
diarrhea; infants; prebiotics; galacto-oligosaccharides; fructo-oligosaccharides; galacturonic oligosaccharides; cytokines
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Vaisman, N.; Press, J.; Leibovitz, E.; Boehm, G.; Barak, V. Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea. Nutrients 2010, 2, 683-692.
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