The Effect of Gymnema Sylvestre on Motivation to Consume Sweet Foods—A Qualitative Investigation
Abstract
1. Introduction
2. Materials and Methods
2.1. Participant Screening and Recruitment
2.2. Study Design
2.3. Interview Methodology
2.3.1. Interview Guide
2.3.2. Baseline Interviews
2.3.3. Post-Treatment Interviews
2.3.4. Final Interviews (Post-All Treatments)
2.4. Data Processing and Analysis
3. Results
3.1. Theme 1—External Influences Affecting SSF Intake
‘I know it’s not good for me. I’m well aware of yeah, just what it is and how much it kind of takes over if you let it take over. I’m very cognitively thinking about everything. I’m like “oh, this does have a bit of sugar in it, probably shouldn’t have eaten that” or “nah, I don’t need that because I don’t need the sugar”.’(Participant 3)
‘If you’re doing a food diary… you have to document what you’re eating. I definitely find that that changes what I eat because I have to start ‘confessing’.’(Participant 5)
‘Cutting down body fat percentage with Summer coming [motivated me to not eat SSF]. I want to look better.’(Participant 4)
3.2. Theme 2—Motivations to Eat or Avoid SSFs
3.2.1. Psychological Motivations
‘There’s been a lot of stress … maybe there’s been a bit of sugar-eating stress relief.’(Participant 1)
‘I’m definitely a boredom eater.’(Participant 3)
‘I didn’t have as much as I’d normally have. I was able to probably stop myself after a few [servings], be like, ‘aw, I’ve had enough’.’(Participant 4)
‘I looked at the sweet chili sauce… I’m actually eating a lot more sugar than what I think I’m eating because all of these extras. And then I took [PLAC-SYS] […] the sweet chili sauce wasn’t as pleasurable […] and then the next day, I thought, ‘you know what, I don’t actually need that sweet chili sauce at all’. So, I had [PLAC-SYS], didn’t have sweet chili sauce, just had the quiche and I was fine.’(Participant 7)
‘You also know that the food you eat after it won’t be quite as satisfying. So, you’re like, OK, this is OK. I can wait or I cannot [have any SSFs] at all.’(Participant 6)
‘It was almost like a self-test. … How badly do I want this sweet thing? Like, you know, am I prepared to have [GS-ADLIB], and then make a specific trip back downstairs in an hour’s time to have [SSF]? … so, it was a little bit like a test.’(Participant 1)
‘In some ways, it’s kind of helped me … learn to not give into the craving straight away. … It does sort of give me that time to go through that process; you know, not be so reactive.’(Participant 5)
3.2.2. Habitual Motivations
‘It’s all around… habit probably. I’ve always had a cup of tea and a biscuit, so it’s my go-to. Growing up was dessert after dinner, biscuits for morning and afternoon tea.’(Participant 1)
‘[My colleagues] actually noticed because when we went to the I, I always order the blueberry muffin with morning coffee. And they were like, “blueberry muffin?” and I was like, “no, not today”. […] That’s how much of in a routine [I was in] that people I work with, and see once a month, know that I always have a blueberry muffin. And I was like, wow, that’s quite a bad habit to me.’(Participant 7)
‘What’s that um experiment, or the study or they’d ring the bell, and it would make the dog salivate or whatever? … Pavlov’s dog, yeah. That’s me with [GS-SYS]. Eat [GS-SYS], and then that’s it, times up.’(Participant 2)
3.2.3. External Motivations
‘If I get busy, and I haven’t had like, my next meal that I usually would have; like a lunch whatever, that can usually mean that I’ll just… eat anything.’(Participant 2)
‘I suppose, the least [I] want to eat it is actually just because I’m busy.’(Participant 7)
‘I did go away for a week. So, I wasn’t around roommates offering me [SSFs].’(Participant 4)
‘Where I work, there’s lots of lovely, yummy goodies, whereas this week being at [my second job], I have occasionally had, like, a little biscuit with my cup of tea. But the access is a lot more limited because you’re with people all the time.’(Participant 6)
“I went on holiday for a few days, had some alcohol and desserts. I wanted to enjoy the holiday, so I didn’t worry about taking [GS-ADLIB] or avoiding [SSF] for those days.”(Participant 3)
3.2.4. Pleasure-Seeking Motivations
‘Obviously like most people I end up eating more than you’d want to, it’s probably a bit of endorphins. The brain knows it tastes good, it gives you energy, once that you have it.’(Participant 4)
‘I do sort of naturally have a sweet tooth. I will intentionally not have sweet foods in the house. If it’s there I will eat it.’(Participant 5)
‘It’s just that taste was so strong in my mouth, definitely it did have a negative effect. I haven’t had big cravings, and then whenever I do I just have [PLAC-SYS] and an hour later I don’t have [them] anymore.’(Participant 4)
‘I did test out having different foods with [GS-SYS], and it was awful. So, I think I had like, a piece of chocolate once, and I was like, this is so gross.’(Participant 2)
‘It’s definitely given me an appreciation for how sweet some things are. Like, to have something that you normally have, and then take all the sensation of sugar out of it, and then bring it back in, it’s like, whoa. Like, sometimes that’s quite a lot, almost to the point where you’re like, oh, this makes me feel a bit a bit peaky.’(Participant 6)
‘It didn’t have a massive effect on my intake of sugary foods … I would just wait for the time frame of [GS-SYS] to wear off, then I’d have something sweet… so overall it didn’t affect how or what I ate.’(Participant 5)
3.2.5. Physiological Motivations
‘Obviously when I cut [weight] I look a lot better than a normal maintenance [weight]. I keep that in mind.’(Participant 4)
‘I guess weight gain would probably be my main [motivation to not consume SSF] … I think it’s just the fear of: if I keep eating this, I’m going to get really fat.’(Participant 5)
‘You’re like “oh god, I still have three hours left of my day” …It’s probably then [I feel like eating SSF the most]. It’s especially during exam time. It’s when your brain is working so hard and you’re so hungry all the time. It’s like, “yeah, let’s just top up with some sugar”.’(Participant 6)
‘My mum thinks carbohydrates are the devil. And so, in my house, we never had dessert, we hardly ever had bread and things like that so like, I think I was always aware that I shouldn’t have too much sweet things.’(Participant 6)
3.3. Themes 3 and 4—Opinions on Each Treatment Arm: Value of Mints
‘It was good at suppressing the ‘want’ for sugary food. [GS-ADLIB] itself is ok, but it made food taste bad.’(Participant 3)
3.4. Theme 5—Changes in Level of Control over SSF Intake
‘Majority of the time I’d say I’m pretty in control. But … there’s a moment where there’s zero control; [I] just eat whatever is in front of me.’(Participant 4)
‘This time it was one hundred percent: I was making all the decisions about the sugar I was taking.’(Participant 7)
4. Discussion
4.1. Summary of Key Findings
4.2. Mindfulness and Behaviour Change
4.3. Gymnema Sylvestre and Taste-Driven Motivation
4.4. Influence of External Factors
4.5. Treatment Preferences and Acceptability
4.6. Self-Control and Intervention Design
4.7. Strengths and Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
GS | Gymnema sylvestre |
GAs | Gymnemic acids |
PLAC | Placebo |
SYS | Systematic trial |
AD-LIB | Ad libitum trial |
SSF | Sugar-sweetened food |
References
- Torres-Fuentes, C.; Schellekens, H.; Dinan, T.G.; Cryan, J.F. A natural solution for obesity: Bioactives for the prevention and treatment of weight gain. A review. Nutr. Neurosci. 2014, 18, 49–65. [Google Scholar] [CrossRef]
- World Health Organization. Obesity and Overweight. 2022. Available online: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight (accessed on 11 January 2022).
- World Health Organization. Guideline: Sugars Intake for Adults and Children; World Health Organization: Geneva, Switzerland, 2015. [Google Scholar]
- Wittekind, A.; Walton, J. Worldwide trends in dietary sugars intake. Nutr. Res. Rev. 2014, 27, 330–345. [Google Scholar] [CrossRef]
- Blades, M. Factors affecting what we eat. Nutr. Food Sci. 2001, 31, 71–74. [Google Scholar] [CrossRef]
- Kirkpatrick, S.I.; Raffoul, A.; Maynard, M.; Lee, K.M.; Stapleton, J. Gaps in the evidence on population interventions to reduce consumption of sugars: A review of reviews. Nutrients 2018, 10, 1036. [Google Scholar] [CrossRef] [PubMed]
- Raine, K.D. Determinants of healthy eating in Canada: An overview and synthesis. Can. J. Public Health 2005, 96, S8–S15. [Google Scholar] [CrossRef] [PubMed]
- Olszewski, P.K.; Wood, E.L.; Klockars, A.; Levine, A.S. Excessive consumption of sugar: An insatiable drive for reward. Curr. Nutr. Rep. 2019, 8, 120–128. [Google Scholar] [CrossRef] [PubMed]
- Eaton, S.B.; Konner, M. Paleolithic nutrition: A consideration of its nature and current implications. N. Engl. J. Med. 1985, 312, 283–289. [Google Scholar] [CrossRef]
- O’Keefe, J.H., Jr.; Cordain, L. Cardiovascular disease resulting from a diet and lifestyle at odds with our Paleolithic genome: How to become a 21st-century hunter-gatherer. Mayo Clin. Proc. 2004, 79, 101–108. [Google Scholar] [CrossRef]
- Wiss, D.A.; Avena, N.; Rada, P. Sugar addiction: From evolution to revolution. Front. Psychiatry 2018, 9, 545. [Google Scholar] [CrossRef]
- Jackson, B.; Cooper, M.L.; Mintz, L.; Albino, A. Motivations to eat: Scale development and validation. J. Res. Pers. 2003, 37, 297–318. [Google Scholar] [CrossRef]
- Pollard, J.; Kirk, S.F.L.; Cade, J.E. Factors affecting food choice in relation to fruit and vegetable intake: A review. Nutr. Res. Rev. 2002, 15, 373–387. [Google Scholar] [CrossRef]
- Schupp, H.T.; Renner, B. Food deprivation: A neuroscientific perspective. In Handbook of Behavior, Food and Nutrition; Springer: Cham, Switzerland, 2011; pp. 2239–2257. [Google Scholar]
- Macht, M.; Simons, G. Emotions and eating in everyday life. Appetite 2000, 35, 65–71. [Google Scholar] [CrossRef]
- Turner, S.; Diako, C.; Kruger, R.; Wong, M.; Wood, W.; Rutherfurd-Markwick, K.; Ali, A. Consuming Gymnema sylvestre Reduces the Desire for High-Sugar Sweet Foods. Nutrients 2020, 12, 1046. [Google Scholar] [CrossRef]
- Armitage, R.M.; Iatridi, V.; Yeomans, M.R. Understanding sweet-liking phenotypes and their implications for obesity: Narrative review and future directions. Physiol. Behav. 2021, 235, 113398. [Google Scholar] [CrossRef] [PubMed]
- Pothuraju, R.; Sharma, R.K.; Chagalamarri, J.; Jangra, S.; Kavadi, P.K. A systematic review of Gymnema sylvestre in obesity and diabetes management. J. Sci. Food Agric. 2013, 94, 834–840. [Google Scholar] [CrossRef] [PubMed]
- Khramov, V.A.; Spasov, A.A.; Samokhina, M.P. Chemical composition of dry extracts of Gymnema sylvestre leaves. Pharm. Chem. J. 2008, 42, 29–31. [Google Scholar] [CrossRef]
- Stice, E.; Yokum, S.; Gau, J.M. Gymnemic acids lozenge reduces short-term consumption of high-sugar food: A placebo controlled experiment. J. Psychopharmacol. 2017, 31, 1496–1502. [Google Scholar] [CrossRef]
- Nobel, S.; Baker, C.; Loullis, C.; Consulting, C.H.A.B. Crave Crush TM lozenges containing gymnemic acids reduce consumption of high sugar foods. Adv. Med. Plant Res. 2017, 5, 63–67. [Google Scholar] [CrossRef]
- Turner, S.; Diako, C.; Kruger, R.; Wong, M.; Wood, W.; Rutherfurd-Markwick, K.; Stice, E.; Ali, A. The Effect of a 14-Day gymnema sylvestre Intervention to Reduce Sugar Cravings in Adults. Nutrients 2022, 14, 5287. [Google Scholar] [CrossRef]
- Kashima, N.; Kimura, K.; Nishitani, N.; Endo, M.Y.; Fukuba, Y.; Kashima, H. Suppression of Oral Sweet Sensations during Consumption of sweet food in humans: Effects on gastric emptying rate, glycemic response, appetite, food satisfaction and desire for basic tastes. Nutrients 2020, 12, 1249. [Google Scholar] [CrossRef]
- Stice, E.; Yokum, S. Effects of gymnemic acids lozenge on reward region response to receipt and anticipated receipt of high-sugar food. Physiol. Behav. 2018, 194, 568–576. [Google Scholar] [CrossRef] [PubMed]
- Devi, K.; Jain, N. Clinical evaluation of the anti-sweet effects of Gymnema sylvestre extract developed into a dispersable oral tablet. J. Herb. Med. 2015, 5, 184–189. [Google Scholar] [CrossRef]
- Goldstein, M.G.; Niaura, R.; Follick, M.J.; Abrams, D.B. Effects of behavioral skills training and schedule of nicotine gum administration on smoking cessation. Am. J. Psychiatry 1989, 146, 56–60. [Google Scholar] [CrossRef]
- Jakše, B.; Jakše, B.; Pajek, J.; Pajek, M. Effects of ad libitum consumed, low-fat, high-fiber plant-based diet supplemented with plant-based meal replacements on cardiovascular risk factors. Food Nutr. Res. 2019, 63, 1560. [Google Scholar] [CrossRef]
- Hsiao, W.H.; Kruger, R.; Diako, C.; Nelson, I.; Stice, E.; Ali, A. The effects of a 14-day Gymnema sylvestre intervention to reduce sugar intake in people self-identifying with a sweet tooth. Appetite 2025, 207, 107871. [Google Scholar] [CrossRef]
- Rehman, A.; Khalid, A. An introduction to research paradigms. Int. J. Educ. Investig. 2016, 3, 51–59. [Google Scholar]
- Jamadagni, P.S.; Pawar, S.D.; Jamadagni, S.B.; Gautam, M.; Gaidhani, S.N.; Prasad, P.G.P.; Gurav, A.M. Recent updates in research on Gymnema sylvestre. Pharmacogn. Rev. 2021, 15, 128–133. [Google Scholar] [CrossRef]
- Fawzy, N.; El-Deen, D.S. Assessment of sugar addiction among non-diabetic patients. IJNRHN 2018, 5, 560–571. [Google Scholar]
- Van Strien, T.; Frijters, J.E.; Bergers, G.P.; Defares, P.B. The Dutch Eating Behavior Questionnaire (DEBQ) for assessment of restrained, emotional, and external eating behavior. Int. J. Eat. Disord. 1986, 5, 295–315. [Google Scholar] [CrossRef]
- Wiriyawattana, P.; Suwonsichon, S.; Suwonsichon, T. Effects of aging on taste thresholds: A case of Asian people. J. Sens. Stud. 2018, 33, e12436. [Google Scholar] [CrossRef]
- Christoph, M.J.; Hazzard, V.M.; Järvelä-Reijonen, E.; Hooper, L.; Larson, N.; Neumark-Sztainer, D. Intuitive eating is associated with higher fruit and vegetable intake among adults. J. Nutr. Educ. Behav. 2021, 53, 240–245. [Google Scholar] [CrossRef]
- Mantzios, M.; Egan, H.; Hussain, M.; Keyte, R.; Bahia, H. Mindfulness, self-compassion, and mindful eating in relation to fat and sugar consumption: An exploratory investigation. Eat. Weight. Disord.-Stud. Anorex. Bulim. Obes. 2018, 23, 833–840. [Google Scholar] [CrossRef]
- Bone, K. Gymnema: A key herb in the management of diabetes. (Phytotherapy Review & Commentary.). Townsend Lett. Dr. Patients 2002, 233, 28–31. [Google Scholar]
- Prochaska, J.O.; DiClemente, C.C. The transtheoretical approach. Handb. Psychother. Integr. 2005, 2, 147–171. [Google Scholar]
- Greene, G.W.; Rossi, S.R.; Rossi, J.S.; Velicer, W.F.; Fava, J.L.; Prochaska, J.O. Dietary applications of the stages of change model. J. Am. Diet. Assoc. 1999, 99, 673–678. [Google Scholar] [CrossRef] [PubMed]
- Mason, A.E.; Epel, E.S.; Kristeller, J.; Moran, P.J.; Dallman, M.; Lustig, R.H.; Acree, M.; Bacchetti, P.; Laraia, B.A.; Hecht, F.M.; et al. Effects of a mindfulness-based intervention on mindful eating, sweets consumption, and fasting glucose levels in obese adults: Data from the SHINE randomized controlled trial. J. Behav. Med. 2015, 39, 201–213. [Google Scholar] [CrossRef] [PubMed]
- Kuchkuntla, A.R.; Limketkai, B.; Nanda, S.; Hurt, R.T.; Mundi, M.S. Fad diets: Hype or hope? Curr. Nutr. Rep. 2018, 7, 310–323. [Google Scholar] [CrossRef] [PubMed]
- Paolini, B.; Burdette, J.H.; Laurienti, P.J.; Morgan, A.R.; Williamson, D.A.; Rejeski, W.J. Coping with brief periods of food restriction: Mindfulness matters. Front. Aging Neurosci. 2012, 4, 23435. [Google Scholar] [CrossRef]
- Simpson, E.H.; Balsam, P.D. The behavioral neuroscience of motivation: An overview of concepts, measures, and translational applications. In Behavioral Neuroscience of Motivation; Current Topics in Behavioral Neurosciences; Springer Nature: Berlin/Heidelberg, Germany, 2016; Volume 27, pp. 1–12. [Google Scholar]
- DiClemente, C.C.; Bellino, L.E.; Neavins, T.M. Motivation for change and alcoholism treatment. Alcohol Res. Health 1999, 23, 86. [Google Scholar]
- Adams, R.C.; Sedgmond, J.; Maizey, L.; Chambers, C.D.; Lawrence, N.S. Food addiction: Implications for the diagnosis and treatment of overeating. Nutrients 2019, 11, 2086. [Google Scholar] [CrossRef]
- Davis, C. An introduction to the Special Issue on ‘food addiction’. Appetite 2017, 115, 1–2. [Google Scholar] [CrossRef]
- Grosshans, M.; Loeber, S.; Kiefer, F. Implications from addiction research towards the understanding and treatment of obesity. Addict. Biol. 2011, 16, 189–198. [Google Scholar] [CrossRef] [PubMed]
- Brown, M.T.; Bussell, J.K. Medication adherence: WHO cares? Mayo Clin. Proc. 2011, 86, 304–314. [Google Scholar] [CrossRef]
- Shapiro, D.H., Jr.; Schwartz, C.E.; Astin, J.A. Controlling ourselves, controlling our world: Psychology’s role in understanding positive and negative consequences of seeking and gaining control. Am. Psychol. 1996, 51, 1213. [Google Scholar] [CrossRef]
- Gerrits, J.H.; O’Hara, R.E.; Piko, B.F.; Gibbons, F.X.; de Ridder, D.T.D.; Keresztes, N.; Kamble, S.V.; de Wit, J.B.F. Self-control, diet concerns and eater prototypes influence fatty foods consumption of adolescents in three countries. Health Educ. Res. 2010, 25, 1031–1041. [Google Scholar] [CrossRef]
- Wills, T.A.; Isasi, C.R.; Mendoza, D.; Ainette, M.G. Self-control constructs related to measures of dietary intake and physical activity in adolescents. J. Adolesc. Health 2007, 41, 551–558. [Google Scholar] [CrossRef] [PubMed]
- De Ridder, D.; Kuijer, R.; Ouwehand, C. Does confrontation with potential goal failure promote self-regulation? Examining the role of distress in the pursuit of weight goals. Psychol. Health 2007, 22, 677–698. [Google Scholar] [CrossRef]
- Kashima, H.; Eguchi, K.; Miyamoto, K.; Fujimoto, M.; Endo, M.Y.; Aso-Someya, N.; Kobayashi, T.; Hayashi, N.; Fukuba, Y. Suppression of oral sweet taste sensation with Gymnema sylvestre affects postprandial gastrointestinal blood flow and gastric emptying in humans. Chem. Senses 2017, 42, 295–302. [Google Scholar] [CrossRef] [PubMed]
- Tong, A.; Sainsbury, P.; Craig, J. Consolidated criteria for reporting qualitative research (COREQ): A 32-item checklist for interviews and focus groups. Int. J. Qual. Health Care 2007, 19, 349–357. [Google Scholar] [CrossRef]
Child Codes | Parent Codes | Quotes | Themes |
---|---|---|---|
External influences related to occupations, daily activities and responsibilities | External influences affecting SSF intake |
| External influences affecting SSF intake |
External influences related to lifestyle changes | |||
External influences related to influence of PLAC-SYS, GS-SYS and GS-ADLIB | |||
Mindfulness and awareness | Psychological motivations |
| Motivations to eat or avoid SSFs |
Emotions | |||
Boredom | |||
Knowledge | External motivations |
| |
Finance | |||
Environment and access | |||
Social factors | |||
Habits | Habit-related motivations |
| |
Wanting | Pleasure-seeking behavioural motivations |
| |
Pleasure and reward | |||
Hormone and cravings | |||
Health | Physiological motivations |
| |
Hunger, satiety and energy | |||
Weight | |||
Negative opinions on mints | Opinions on mints |
| Opinions on treatment arms |
Positive opinions on mints | |||
Mixed opinions on mints | |||
Which mint would participants accept for free | Value of mints |
| |
Which mint would participants pay for | |||
Feeling more in control over SSF intake | Changes in level of control over SSF intake |
| Changes in level of control over SSF intake |
Feeling less in control over SSF intake |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Nelson, I.; Kruger, R.; Hsiao, D.; Stice, E.; Ali, A. The Effect of Gymnema Sylvestre on Motivation to Consume Sweet Foods—A Qualitative Investigation. Nutrients 2025, 17, 2718. https://doi.org/10.3390/nu17172718
Nelson I, Kruger R, Hsiao D, Stice E, Ali A. The Effect of Gymnema Sylvestre on Motivation to Consume Sweet Foods—A Qualitative Investigation. Nutrients. 2025; 17(17):2718. https://doi.org/10.3390/nu17172718
Chicago/Turabian StyleNelson, Imogen, Rozanne Kruger, David Hsiao, Eric Stice, and Ajmol Ali. 2025. "The Effect of Gymnema Sylvestre on Motivation to Consume Sweet Foods—A Qualitative Investigation" Nutrients 17, no. 17: 2718. https://doi.org/10.3390/nu17172718
APA StyleNelson, I., Kruger, R., Hsiao, D., Stice, E., & Ali, A. (2025). The Effect of Gymnema Sylvestre on Motivation to Consume Sweet Foods—A Qualitative Investigation. Nutrients, 17(17), 2718. https://doi.org/10.3390/nu17172718