Longitudinal Examination of Body Mass Index and Cognitive Function in Older Adults: The HELIAD Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Participants
2.2. Anthropometry
2.3. Neuropsychological Evaluation
2.4. Neurological Evaluation and Clinical Diagnosis
2.5. Assessment of Depressive Symptoms/Depression
2.6. Other Variables
2.7. Statistical Analyses
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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≤75 Years Old (Ν = 715) | >75 Years Old (Ν = 361) | p-Value * | |
---|---|---|---|
Sex (% females) | 65.5% | 48.2% | <0.001 |
Education (years) | 8.7 ± 4.7 | 7.0 ± 5.1 | <0.001 |
Body mass index (kg/m2) | |||
at baseline | 29.0 ± 4.6 | 28.7 ± 4.2 | 0.365 |
at follow-up | 29.2 ± 4.7 | 28.7 ± 4.4 | 0.104 |
Body weight (kg) | |||
at baseline | 75.8 ± 12.9 | 75.0 ± 12.2 | 0.284 |
at follow-up | 76.1 ± 13.2 | 74.8 ± 12.8 | 0.122 |
APOE-ε4 carriage (% carrying one or two ε4 alleles) | 19.3% | 12.6% | 0.001 |
Depression (% yes) | 20.4% | 18.6% | 0.517 |
Sum of comorbidities | 2.0 ± 1.4 | 2.2 ± 1.5 | 0.094 |
Global cognition | 0.20 ± 0.60 | −0.44 ± 0.83 | <0.001 |
Executive functioning | 0.19 ± 0.63 | −0.39 ± 0.86 | <0.001 |
Memory | 0.23 ± 0.83 | −0.44 ± 0.90 | <0.001 |
Attention/Processing speed | 0.17 ± 0.87 | −0.64 ± 1.30 | <0.001 |
Language | 0.25 ± 0.69 | −0.34 ± 1.01 | <0.001 |
Visuospatial ability | 0.19 ± 0.62 | −0.38 ± 1.12 | <0.001 |
≤75 Years Old | >75 Years Old | ||||
---|---|---|---|---|---|
BMI Trajectories | β (±SE) | p-Value | β (±SE) | p-Value | |
Global cognition | |||||
Normal → Normal (reference) | |||||
Normal → Overweight or Obesity | 0.012 ± 0.0285 | 0.680 | 0.004 ± 0.0578 | 0.949 | |
Overweight → Normal | 0.044 ± 0.0352 | 0.210 | −0.002 ± 0.0400 | 0.952 | |
Overweight → Overweight or Obesity | −0.029 ± 0.0216 | 0.178 | −0.012 ± 0.0401 | 0.756 | |
Obesity → Overweight or Normal | 0.027 ± 0.0519 | 0.600 | 0.018 ± 0.0420 | 0.665 | |
Obesity → Obesity | −0.024 ± 0.0227 | 0.282 | −0.029 ± 0.0378 | 0.442 | |
Executive functioning | |||||
Normal → Normal (reference) | |||||
Normal → Overweight or Obesity | 0.006 ± 0.0396 | 0.880 | 0.059 ± 0.0620 | 0.338 | |
Overweight → Normal | 0.078 ± 0.0516 | 0.129 | −0.022 ± 0.0746 | 0.765 | |
Overweight → Overweight or Obesity | −0.011 ± 0.0249 | 0.657 | 0.017 ± 0.0472 | 0.725 | |
Obesity → Overweight or Normal | −0.001 ± 0.0476 | 0.990 | 0.059 ± 0.0495 | 0.231 | |
Obesity → Obesity | −0.001 ± 0.0269 | 0.980 | −0.025 ± 0.0503 | 0.626 | |
Memory | |||||
Normal → Normal (reference) | |||||
Normal → Overweight or Obesity | 0.050 ± 0.0590 | 0.402 | 0.059 ± 0.0894 | 0.507 | |
Overweight → Normal | 0.073 ± 0.0548 | 0.184 | 0.145 ± 0.0805 | 0.071 | |
Overweight → Overweight or Obesity | −0.001 ± 0.0396 | 0.984 | 0.046 ± 0.0485 | 0.340 | |
Obesity → Overweight or Normal | 0.141 ± 0.0671 | 0.035 | 0.077 ± 0.0737 | 0.297 | |
Obesity → Obesity | 0.017 ± 0.0396 | 0.665 | 0.102 ± 0.0501 | 0.042 | |
Attention/Processing speed | |||||
Normal → Normal (reference) | |||||
Normal → Overweight or Obesity | −0.068 ± 0.0485 | 0.164 | 0.177 ± 0.1436 | 0.218 | |
Overweight → Normal | −0.005 ± 0.0518 | 0.918 | −0.275 ± 0.1360 | 0.043 | |
Overweight → Overweight or Obesity | −0.053 ± 0.0347 | 0.128 | −0.039 ± 0.0857 | 0.652 | |
Obesity → Overweight or Normal | −0.089 ± 0.1136 | 0.433 | −0.118 ± 0.1153 | 0.306 | |
Obesity → Obesity | −0.066 ± 0.0363 | 0.068 | −0.167 ± 0.0945 | 0.077 | |
Language | |||||
Normal → Normal (reference) | |||||
Normal → Overweight or Obesity | 0.021 ± 0.0428 | 0.625 | −0.028 ± 0.0673 | 0.675 | |
Overweight → Normal | 0.090 ± 0.0490 | 0.065 | 0.018 ± 0.0743 | 0.805 | |
Overweight → Overweight or Obesity | 0.011 ± 0.0282 | 0.689 | −0.001 ± 0.0587 | 0.987 | |
Obesity → Overweight or Normal | 0.017 ± 0.0598 | 0.776 | 0.052 ± 0.0683 | 0.448 | |
Obesity → Obesity | −0.004 ± 0.0307 | 0.909 | −0.015 ± 0.0607 | 0.808 | |
Visuospatial ability | |||||
Normal → Normal (reference) | |||||
Normal → Overweight or Obesity | 0.023 ± 0.0432 | 0.602 | −0.153 ± 0.0792 | 0.053 | |
Overweight → Normal | −0.051 ± 0.0496 | 0.303 | 0.041 ± 0.0759 | 0.591 | |
Overweight → Overweight or Obesity | −0.093 ± 0.0398 | 0.020 | −0.048 ± 0.0644 | 0.460 | |
Obesity → Overweight or Normal | 0.025 ± 0.0736 | 0.734 | −0.017 ± 0.0848 | 0.838 | |
Obesity → Obesity | −0.061 ± 0.0383 | 0.112 | −0.040 ± 0.0595 | 0.503 |
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Grapsa, I.; Mamalaki, E.; Ntanasi, E.; Kosmidis, M.H.; Dardiotis, E.; Hadjigeorgiou, G.M.; Sakka, P.; Scarmeas, N.; Yannakoulia, M. Longitudinal Examination of Body Mass Index and Cognitive Function in Older Adults: The HELIAD Study. Nutrients 2023, 15, 1795. https://doi.org/10.3390/nu15071795
Grapsa I, Mamalaki E, Ntanasi E, Kosmidis MH, Dardiotis E, Hadjigeorgiou GM, Sakka P, Scarmeas N, Yannakoulia M. Longitudinal Examination of Body Mass Index and Cognitive Function in Older Adults: The HELIAD Study. Nutrients. 2023; 15(7):1795. https://doi.org/10.3390/nu15071795
Chicago/Turabian StyleGrapsa, Ismini, Eirini Mamalaki, Eva Ntanasi, Mary H. Kosmidis, Efthimios Dardiotis, Georgios M. Hadjigeorgiou, Paraskevi Sakka, Nikolaos Scarmeas, and Mary Yannakoulia. 2023. "Longitudinal Examination of Body Mass Index and Cognitive Function in Older Adults: The HELIAD Study" Nutrients 15, no. 7: 1795. https://doi.org/10.3390/nu15071795
APA StyleGrapsa, I., Mamalaki, E., Ntanasi, E., Kosmidis, M. H., Dardiotis, E., Hadjigeorgiou, G. M., Sakka, P., Scarmeas, N., & Yannakoulia, M. (2023). Longitudinal Examination of Body Mass Index and Cognitive Function in Older Adults: The HELIAD Study. Nutrients, 15(7), 1795. https://doi.org/10.3390/nu15071795