The Role of Nutrition in Pathogenesis of Uterine Fibroids
Abstract
:1. Introduction
2. Methodology
3. Vegetables and Fruits
4. Dairy
5. Soybean
6. Green Tea Extracts
7. Selenium
8. Curcumin
9. Cereal
10. Vitamins
10.1. Vitamin D
10.2. Vitamin C
10.3. Vitamin A
10.4. Vitamin E
10.5. Vitamin B3
11. Strengths and Limitations of Available Studies
12. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Reference | Group | Country | Outcome | |
---|---|---|---|---|
Vegetables and fruits | Zhou, 2020 [8] | 248 women; 37 patients with uterine fibroids (UF) | China | Carrot, kiwi and seaweed intake inversely associated with the risk of fibroids |
Wise, 2011 [16] | 22,583 women 6627 patients with UF | USA | Inverse association between fruits and vegetables intake and UF | |
Davis, 2023 [17] | 9706 patients with UFs confirmed by ultrasound or hysterectomy | USA | Lower risk of fibroids in patients with highest intake of fruits Inverse association between amount of pesticide residues and UF risk | |
Shen, 2016 [18] | 600 Chinese Han women with and 600 without UF | China | Lower intake of broccoli, cabbage, Chinese cabbage, tomato and apple in patients with UF | |
He, 2013 [19] | 73 women with and 210 without UF | China | Vegetable and fruit intake reduces the risk of UF | |
Dairy products | Orta, 2020 [20] | 81,590 women; 8142 cases of ultrasound or hysterectomy confirmed UF | USA | Inverse correlation between yogurt intake and UF risk |
Wise, 2010 [21] | 22,120 women; 5871 cases of UF | USA | Weak inverse correlation of yogurt intake and UF | |
Gao, 2018 [22] | 213 patients with UFs and 1060 without | China | Frequent milk or soy consumption is a risk factor for UF | |
Soy foods | Yang, 2023 [9] | 1579 participants form the National Health and Nutrition Examination Survey; 204 patients with UF | China | Positive correlation between mixed metabolites of urinary phytoestrogens and UFs, with greatest impact from equol. |
Upson, 2016 [23] | 1553 African American women; 345 cases of UF detected with ultrasound | USA | Soy intake during infancy correlated with larger fibroid size | |
Simon, 2015 [24] | 157 patients with UF and 171 without | Jamaica | Higher urine enterolactone levels in UF patients. No association with increased risk of UF. | |
Gao, 2018 [22] | 213 patients with UF and 1060 without | China | Frequent milk or soy consumption is a risk factor for UF | |
Wise, 2010 [21] | 22,120 women; 5871 cases of UF | USA | No association between soy intake and UF | |
Green tea | Roshdy, 2013 [25] | 22 women treated with 800 mg of green tea extract and 11 with placebo | USA | Reduced symptoms and size of fibroids in the study group |
Biro, 2021 [26] | 25 women with UF | Germany | Green tea extract associated with higher quality of life. No change in UF size | |
Cereal | He, 2013 [19] | 73 women with and 210 without UF | China | No association between cereal consumption and UF |
Vitamin D | Ciebiera, 2016 [27] | 105 women with and 83 without UF | Poland | Lower levels of serum 25-hydroxyvitamin D (25OHD) in patients with UF |
Li, 2020 [28] | 279 women with and 267 without UF | China | Lower levels of serum 25OHD in patients with UF | |
Ciavattini, 2016 [29] | 108 patients with UF; 53 underwent vitamin D supplementation (study group) | Italy | Lower surgical or medical treatment rates in study group | |
Harmon, 2022 [30] | 1610 women without previous diagnosis of UF | USA | Serum 25-OHD > 20 ng/mL associated with reduction in UF growth; >30 ng/mL associated with decreased incidence of UF. | |
Vitamin C | Wise, 2010, [21] | 22,120 women; 5871 cases of UF | USA | No association between vitamin E intake and the incidence of UF |
Vitamin A | Wise, 2010 [21] | 22,120 women; 5871 cases of UF | USA | Animal derived vitamin A inversely associated with UF risk |
Wise, 2021 [31] | 1230 patients; 301 cases of UF diagnosed in 5-year follow up | USA | No association between intake of lycopene or other carotenoids and UF incidence | |
Martin, 2011 [32] | 887 patients; 68 with self-reported UF | USA | Patients with middle and higher levels of vitamin A are at increased risk of UF | |
Vitamin E | Wise, 2010 [21] | 22,120 women; 5871 cases of UF | USA | No association between vitamin E intake and the incidence of UF |
Martin, 2011 [32] | 887 patients; 68 with self-reported UF | USA | No association between vitamin E and UF | |
Ciebiera, 2018 [33] | 162 patients; 100 cases of UF | Poland | Lower levels of alpha tocopherol in patients with UF | |
Vitamin B3 | No studies on humans found |
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Krzyżanowski, J.; Paszkowski, T.; Woźniak, S. The Role of Nutrition in Pathogenesis of Uterine Fibroids. Nutrients 2023, 15, 4984. https://doi.org/10.3390/nu15234984
Krzyżanowski J, Paszkowski T, Woźniak S. The Role of Nutrition in Pathogenesis of Uterine Fibroids. Nutrients. 2023; 15(23):4984. https://doi.org/10.3390/nu15234984
Chicago/Turabian StyleKrzyżanowski, Jarosław, Tomasz Paszkowski, and Sławomir Woźniak. 2023. "The Role of Nutrition in Pathogenesis of Uterine Fibroids" Nutrients 15, no. 23: 4984. https://doi.org/10.3390/nu15234984