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Nutrients
Volume 15
Issue 21
10.3390/nu15214598
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Article

Pro-Inflammatory Diets Are Associated with Frailty in an Urban Middle-Aged African American and White Cohort

by
Marie Fanelli Kuczmarski
*,
May A. Beydoun
,
Michael F. Georgescu
,
Nicole Noren Hooten
,
Nicolle A. Mode
,
Michele K. Evans
and
Alan B. Zonderman
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
*
Author to whom correspondence should be addressed.
Nutrients 2023, 15(21), 4598; https://doi.org/10.3390/nu15214598
Submission received: 13 October 2023 / Revised: 24 October 2023 / Accepted: 27 October 2023 / Published: 29 October 2023
(This article belongs to the Special Issue Nutrition and Lifestyle Interventions for Frailty and Sarcopenia)
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Abstract

Diet quality is a modifiable risk factor for frailty, but research on the association of frailty with dietary inflammatory potential is limited. The objective was to determine associations between diet quality assessed by the dietary inflammatory index (DII) with frailty status over time. Participants with both dietary and frailty data from the longitudinal Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study were used (n = 2901, 43.5% male, 43.8% African American, 48.5 y mean baseline age, with a mean 8.7 y of follow-up). Group-based trajectory modeling identified two frailty (remaining non-frail or being pre-frail/frail over time) and three diet quality trajectory groups (high or medium pro-inflammatory and anti-inflammatory potentials). Multiple logistic regression found both medium pro-inflammatory and anti-inflammatory DII trajectory groups, compared to the high pro-inflammatory group, were positively associated with being non-frail over time for the overall sample, both sexes and races. Kaplan–Meier curves and log-rank test revealed anti-inflammatory DII scores were associated with lower risk for being pre-frail or frail. No longitudinal relationship existed between frailty status at baseline and annualized DII change, a check on reverse causality. This study contributes to our current knowledge providing longitudinal evidence of the link between anti-inflammatory DII score with lower frailty risk.
Keywords: diet quality; dietary inflammatory index; pre-frail; nutrition; group-based trajectory modeling diet quality; dietary inflammatory index; pre-frail; nutrition; group-based trajectory modeling

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MDPI and ACS Style

Kuczmarski, M.F.; Beydoun, M.A.; Georgescu, M.F.; Noren Hooten, N.; Mode, N.A.; Evans, M.K.; Zonderman, A.B. Pro-Inflammatory Diets Are Associated with Frailty in an Urban Middle-Aged African American and White Cohort. Nutrients 2023, 15, 4598. https://doi.org/10.3390/nu15214598

AMA Style

Kuczmarski MF, Beydoun MA, Georgescu MF, Noren Hooten N, Mode NA, Evans MK, Zonderman AB. Pro-Inflammatory Diets Are Associated with Frailty in an Urban Middle-Aged African American and White Cohort. Nutrients. 2023; 15(21):4598. https://doi.org/10.3390/nu15214598

Chicago/Turabian Style

Kuczmarski, Marie Fanelli, May A. Beydoun, Michael F. Georgescu, Nicole Noren Hooten, Nicolle A. Mode, Michele K. Evans, and Alan B. Zonderman. 2023. "Pro-Inflammatory Diets Are Associated with Frailty in an Urban Middle-Aged African American and White Cohort" Nutrients 15, no. 21: 4598. https://doi.org/10.3390/nu15214598

APA Style

Kuczmarski, M. F., Beydoun, M. A., Georgescu, M. F., Noren Hooten, N., Mode, N. A., Evans, M. K., & Zonderman, A. B. (2023). Pro-Inflammatory Diets Are Associated with Frailty in an Urban Middle-Aged African American and White Cohort. Nutrients, 15(21), 4598. https://doi.org/10.3390/nu15214598

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