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Editorial

Effects of Nutritional Interventions on Athletic Performance

1
Human Physiology & Sport Physiotherapy Research Group, Vrije Universiteit Brussel, 1050 Ixelles, Belgium
2
Department of Physical Therapy Education, Elon University, Elon, NC 27244, USA
*
Author to whom correspondence should be addressed.
Nutrients 2023, 15(21), 4498; https://doi.org/10.3390/nu15214498
Submission received: 3 October 2023 / Accepted: 10 October 2023 / Published: 24 October 2023
(This article belongs to the Special Issue Effects of Nutritional Interventions on Athletic Performance)
The search to comprehend the fundamental physiological factors that contribute to the exceptional endurance performance of elite human athletes is a long-standing endeavor within the field of sports science research [1]. Even today, this search remains a central focus. Currently, a significant portion of research is aimed at unravelling the role of nutritional interventions in athletic performance. As stated in the IOC consensus statement, athletes use dietary supplementation (among others) for supporting their energy metabolism, correcting deficiencies, and achieving either direct or indirect ergogenic effects [2]. There are many systematic reviews [3,4,5,6,7] and consensus statements [2,8,9,10,11] on athletes’ dietary supplementation, especially for macronutrients (e.g., glucose, protein, and ketone supplementation, among others) and micronutrients (e.g., nitrate, vitamin, caffeine, and electrolyte supplementation, among others). Therefore this editorial is focused on the emerging, but yet to be further researched, supplementation with substances (i.e., probiotics, prebiotics, and short-chain fatty acids (SCFAs)) that affect the gut microbiome. The gastrointestinal tract (GIT) is inhabited by trillions of not only bacteria, but also viruses, fungi, and archaea [12]. With approximately nine million genes [13], this environment represents the human gut microbiome, which makes up a complex ecological community by which an individual lives in a symbiotic manner all his life [14]. The gut microbiome has versatile functions, such as energy production, regulating the immune system, producing hormones, and communicating with the brain [8,15]. This has ensured that, in the last ten years, a significant interest in understanding the connection between exercise and the gut microbiome has arisen.
Emerging from preliminary observations in both animal and human models, interventions that focus on optimizing the microbial balance have showcased improvements in exercise capacity. Consequently, it is becoming evident that the gut microbiota might constitute an untapped factor in influencing exercise performance. Strategies that externally target the gut microbiota offer a new opportunity for augmenting human exercise tolerance, capacity, and overall performance. This editorial therefore aims to uncover the ways in which the gut microbiome could be harnessed (i.e., with probiotics, prebiotics, and SCFAs) to improve exercise tolerance and capacity.
Prebiotics and probiotics comprise a family of substances that modulate the gut microbiota and collectively can be referred to as ‘biotics’ [16]. The utilization of biotics to augment the abundance of beneficial bacterial species (probiotics) or to nourish the existing commensal bacterial species (prebiotics) represents an exogenous approach to enhance the structure and function of the gut microbiota [17]. Probiotics are defined as “live microorganisms that confer a health benefit to the host when administered in adequate amounts”. They are mostly administered in the form of singular, or blends of, Lactobacillus and Bifidobacterium strains [18,19].
Studies from 2019 to 2022 have demonstrated that supplementing mice with various single bacteria strains led to an improved endurance exercise capacity [20,21,22,23,24,25,26], likely through their effect on the energy metabolism, intestinal barrier integrity, and overall host health [27,28,29,30]. This is further supported by the position stand of the International Society of Sports Nutrition, which affirms that probiotic supplementation can mitigate an increased gut permeability resulting from intense, prolonged exercise, particularly in hot conditions [31].
To this day, human studies on probiotic supplementation in general mostly use commercially available probiotics and not a specifically targeted strain of bacteria, as in the above-mentioned mice studies. However, a review on these human studies also showed a positive effect on aerobic performance in trained individuals [32]. According to the same study, a supplementation period of less than 4 weeks with a single-strain probiotic might give the most promising results. Aerobic performance is the most studied parameter so far; nevertheless, an increased anaerobic performance among mixed martial arts athletes was also found when combining probiotics with vitamin D3 [33].
Within athletic populations, specific strains of probiotics have the potential to enhance the absorption of essential nutrients such as amino acids from protein, consequently influencing the pharmacological and physiological attributes of various food constituents [31]. However, according to another review, too little is known about the effects of the gut microbiome, and, therefore, about biotic supplementation, with regard to the ergogenic effects of most dietary supplements [34]. Lastly, the addition of probiotics to the diet has been shown to decrease the occurrence, duration, and intensity of upper respiratory tract infections, potentially leading to indirect enhancements in training or competitive performance [6,35]. Following this, an improved recovery from muscle damage is shown during probiotic supplementation [31]. However, the impact of variations in the gut microbiota composition on the effectiveness of probiotics remains uncertain [31].
In summary, a moderate number of direct and indirect ergogenic effects of probiotics have been discovered, making probiotic supplementation a promising ergogenic intervention for athletes. However, more specific research is needed in consideration of specific bacterial strains, different populations, different types of physical performance, and dose–response relationships, as well as their effect on other dietary supplementations.
A prebiotic is a substance that is selectively metabolized by indigenous microorganisms in the host, providing a health advantage. It is present in non-digestible compounds such as oligosaccharides, galactans, and fructans [36]. A whole list of potential fiber and prebiotic types, as well as their effect on host physiology, can be found in the study of Bongiovanni and colleagues [37]. The consumption of particular dietary components, namely prebiotics and fiber, is widely recognized for conferring numerous health benefits [38]. Dietary fibers, in addition to promoting bowel regularity, play a vital role in maintaining gut health through a diverse array of phytochemicals and metabolites, including SCFAs [39,40]. This underscores the importance of an adequate fiber intake for everyone, including athletes. Individual tolerance to fiber and prebiotics varies. Modest reductions in the consumption of fiber-rich foods may be due, in part, to discomforts such as bloating, cramps, and increased flatulence that are experienced post-fiber consumption [41]. This is a crucial consideration when devising nutritional plans for athletes, particularly when aiming to boost fiber intake, and especially during competitions. Because of these possible discomforts, athletes often follow diets that are high in carbohydrates and protein, but with a lower fiber intake, matching their energy needs for training and competitions. A reduced fiber intake shifts microbial fermentation towards less-favorable substrates such as proteins and fats, decreasing SCFA production [42,43]. Notably, just a brief 24 h shift in the macronutrient balance can alter the microbial community, influencing the preference for carbohydrates over proteins [44,45]. Furthermore, a study in mice with both high and low levels of accessible, non-fermentable carbohydrates for the microbiota showed shorter run times in the low-level accessible group [46]. These effects were reversed when those mice (low) received a prebiotic combined with fecal transplantation from the other group (high). This study highlights the important role of prebiotics (and food strategy) in physical performance. Subsequent research should be structured to investigate the augmentation of circulating SCFAs through prebiotic and fiber consumption in relation to exercise performance and recovery, taking in account the possible GIT discomforts [37].
The use of postbiotics has surfaced more recently, and is characterized as a “preparation of inanimate microorganisms and/or their components that confers a health benefit on the host” [47]. Postbiotics encompass deactivated microbial cells or cellular constituents, potentially accompanied by metabolites such as SCFAs [48]. It should be noted that the accessibility of such supplements in the commercial market is upcoming, but still limited. However, the isolated supplementation of SCFAs in a physical performance context is already more investigated.
Bacterial fermentation yields SCFAs such as acetate, propionate, and butyrate. Their production ratio is approximately 60:20:20, but this can vary [49,50]. SCFA levels peak in the proximal colon (70–140 mM), whilst decreasing in the distal colon (20–70 mM). Around 95% of SCFAs are absorbed by colon cells, with the remaining 5% being excreted in feces [49,50]. Butyrate is the main energy source for colon cells, promoting intestinal health [51]. Acetate and propionate are also used, but to a lesser extent [52]. Unused SCFAs travel to the liver, where they can be used for energy or enter the bloodstream, benefiting various organs. Recent findings suggest that SCFAs may influence the skeletal muscle metabolism via specific receptors (GPR41 and GPR43) [53,54]. This is significant for understanding the exercise-related energy metabolism.
As further investigated by Scheiman and colleagues, a rectal supplementation with propionate increased running times in mice during a time to exhaustion (TTE) test compared to saline supplementation [25]. Additionally, infusing acetate into microbiota-depleted mice improved treadmill run times, emphasizing its role in exercise performance [46]. These studies show that acetate and propionate have restorative and potentially performance-enhancing effects. Additionally, research on mice lacking Acetyl-CoA synthetase 2 confirms that microbiota-generated acetate is crucial for the skeletal muscle metabolism and may influence exercise tolerance [55]. Acetate availability to tissues with SCFA receptors, including the skeletal muscles, suggests that interventions that involve increasing acetate bioavailability could improve exercise tolerance. In humans, SCFAs have been linked to the stimulation of mitochondrial biogenesis and the promotion of endurance performance [56]. Hence, elevating the presence of SCFAs in the system could be a novel approach to enhance exercise capacity, offering an extra energy source to active tissues. However, the impact under various pre-exercise feeding conditions is unclear [19].
To conclude, further investigation is required to understand the specific direct or indirect mechanisms, as well as the potential interactions, through which gut-derived SCFAs might impact exercise performance.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Joyner, M.J.; Coyle, E.F. Endurance exercise performance: The physiology of champions. J. Physiol. 2008, 586, 35–44. [Google Scholar] [CrossRef] [PubMed]
  2. Maughan, R.J.; Burke, L.M.; Dvorak, J.; Larson-Meyer, D.E.; Peeling, P.; Phillips, S.M.; Rawson, E.S.; Walsh, N.P.; Garthe, I.; Geyer, H. IOC consensus statement: Dietary supplements and the high-performance athlete. Int. J. Sport Nutr. Exerc. Metab. 2018, 28, 104–125. [Google Scholar] [CrossRef] [PubMed]
  3. Ganio, M.S.; Klau, J.F.; Casa, D.J.; Armstrong, L.E.; Maresh, C.M. Effect of caffeine on sport-specific endurance performance: A systematic review. J. Strength Cond. Res. 2009, 23, 315–324. [Google Scholar] [CrossRef]
  4. Jones, A.M. Influence of dietary nitrate on the physiological determinants of exercise performance: A critical review. Appl. Physiol. Nutr. Metab. 2014, 39, 1019–1028. [Google Scholar] [CrossRef] [PubMed]
  5. Peeling, P.; Binnie, M.J.; Goods, P.S.; Sim, M.; Burke, L.M. Evidence-based supplements for the enhancement of athletic performance. Int. J. Sport Nutr. Exerc. Metab. 2018, 28, 178–187. [Google Scholar] [CrossRef] [PubMed]
  6. Rawson, E.S.; Miles, M.P.; Larson-Meyer, D.E. Dietary supplements for health, adaptation, and recovery in athletes. Int. J. Sport Nutr. Exerc. Metab. 2018, 28, 188–199. [Google Scholar] [CrossRef]
  7. Stellingwerff, T.; Cox, G.R. Systematic review: Carbohydrate supplementation on exercise performance or capacity of varying durations. Appl. Physiol. Nutr. Metab. 2014, 39, 998–1011. [Google Scholar] [CrossRef]
  8. Bermon, S.; Castell, L.M.; Calder, P.C.; Bishop, N.C.; Blomstrand, E.; Mooren, F.C.; Krüger, K.; Kavazis, A.N.; Quindry, J.C.; Senchina, D.S. Consensus statement immunonutrition and exercise. Exerc. Immunol. Rev. 2017, 23, 8–50. [Google Scholar]
  9. Burke, L.M. The IOC consensus on sports nutrition 2003: New guidelines for nutrition for athletes. Int. J. Sport Nutr. Exerc. Metab. 2003, 13, 549–552. [Google Scholar] [CrossRef]
  10. Gibson, R.S. Principles of Nutritional Assessment; Oxford University Press: New York, NY, USA, 2005. [Google Scholar]
  11. Thomas, D.T.; Erdman, K.A.; Burke, L.M. Nutrition and athletic performance. Med. Sci. Sports Exerc. 2016, 48, 543–568. [Google Scholar]
  12. Flint, H.J.; Scott, K.P.; Louis, P.; Duncan, S.H. The role of the gut microbiota in nutrition and health. Nat. Rev. Gastroenterol. Hepatol. 2012, 9, 577–589. [Google Scholar] [CrossRef] [PubMed]
  13. Li, J.; Jia, H.; Cai, X.; Zhong, H.; Feng, Q.; Sunagawa, S.; Arumugam, M.; Kultima, J.R.; Prifti, E.; Nielsen, T. An integrated catalog of reference genes in the human gut microbiome. Nat. Biotechnol. 2014, 32, 834–841. [Google Scholar] [CrossRef] [PubMed]
  14. Hoffmann, C.; Dollive, S.; Grunberg, S.; Chen, J.; Li, H.; Wu, G.D.; Lewis, J.D.; Bushman, F.D. Archaea and fungi of the human gut microbiome: Correlations with diet and bacterial residents. PLoS ONE 2013, 8, e66019. [Google Scholar] [CrossRef]
  15. Foster, J.A.; Rinaman, L.; Cryan, J.F. Stress & the gut-brain axis: Regulation by the microbiome. Neurobiol. Stress 2017, 7, 124–136. [Google Scholar] [PubMed]
  16. Kocot, A.M.; Jarocka-Cyrta, E.; Drabińska, N. Overview of the importance of biotics in gut barrier integrity. Int. J. Mol. Sci. 2022, 23, 2896. [Google Scholar] [CrossRef]
  17. Holzapfel, W.H.; Schillinger, U. Introduction to pre-and probiotics. Food Res. Int. 2002, 35, 109–116. [Google Scholar] [CrossRef]
  18. Hill, C.; Guarner, F.; Reid, G.; Gibson, G.R.; Merenstein, D.J.; Pot, B.; Morelli, L.; Canani, R.B.; Flint, H.J.; Salminen, S. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat. Rev. Gastroenterol. Hepatol. 2014, 11, 506–514. [Google Scholar] [CrossRef]
  19. Sales, K.M.; Reimer, R.A. Unlocking a novel determinant of athletic performance: The role of the gut microbiota, short-chain fatty acids, and “biotics” in exercise. J. Sport Health Sci. 2023, 12, 36–44. [Google Scholar] [CrossRef]
  20. Bloemen, J.G.; Venema, K.; van de Poll, M.C.; Damink, S.W.O.; Buurman, W.A.; Dejong, C.H. Short chain fatty acids exchange across the gut and liver in humans measured at surgery. Clin. Nutr. 2009, 28, 657–661. [Google Scholar] [CrossRef]
  21. Egland, P.G.; Palmer Jr, R.J.; Kolenbrander, P.E. Interspecies communication in Streptococcus gordonii–Veillonella atypica biofilms: Signaling in flow conditions requires juxtaposition. Proc. Natl. Acad. Sci. USA 2004, 101, 16917–16922. [Google Scholar] [CrossRef]
  22. Lee, M.-C.; Hsu, Y.-J.; Chuang, H.-L.; Hsieh, P.-S.; Ho, H.-H.; Chen, W.-L.; Chiu, Y.-S.; Huang, C.-C. In vivo ergogenic properties of the Bifidobacterium longum OLP-01 isolated from a weightlifting gold medalist. Nutrients 2019, 11, 2003. [Google Scholar] [CrossRef]
  23. Lee, M.-C.; Hsu, Y.-J.; Ho, H.-H.; Hsieh, S.-H.; Kuo, Y.-W.; Sung, H.-C.; Huang, C.-C. Lactobacillus salivarius subspecies salicinius SA-03 is a new probiotic capable of enhancing exercise performance and decreasing fatigue. Microorganisms 2020, 8, 545. [Google Scholar] [CrossRef]
  24. Lee, M.-C.; Chen, M.-J.; Huang, H.-W.; Wu, W.-K.; Lee, Y.-W.; Kuo, H.-C.; Huang, C.-C. Probiotic Lactiplantibacillus plantarum Tana isolated from an international weightlifter enhances exercise performance and promotes antifatigue effects in mice. Nutrients 2022, 14, 3308. [Google Scholar] [CrossRef] [PubMed]
  25. Scheiman, J.; Luber, J.M.; Chavkin, T.A.; MacDonald, T.; Tung, A.; Pham, L.-D.; Wibowo, M.C.; Wurth, R.C.; Punthambaker, S.; Tierney, B.T. Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism. Nat. Med. 2019, 25, 1104–1109. [Google Scholar] [CrossRef] [PubMed]
  26. Tan, J.; McKenzie, C.; Potamitis, M.; Thorburn, A.N.; Mackay, C.R.; Macia, L. The role of short-chain fatty acids in health and disease. Adv. Immunol. 2014, 121, 91–119. [Google Scholar]
  27. Bron, P.A.; Kleerebezem, M.; Brummer, R.-J.; Cani, P.D.; Mercenier, A.; MacDonald, T.T.; Garcia-Ródenas, C.L.; Wells, J.M. Can probiotics modulate human disease by impacting intestinal barrier function? Br. J. Nutr. 2017, 117, 93–107. [Google Scholar] [CrossRef] [PubMed]
  28. Camilleri, á.; Madsen, K.; Spiller, R.; Van Meerveld, B.; Verne, G. Intestinal barrier function in health and gastrointestinal disease. Neurogastroenterol. Motil. 2012, 24, 503–512. [Google Scholar] [CrossRef] [PubMed]
  29. Ohland, C.L.; MacNaughton, W.K. Probiotic bacteria and intestinal epithelial barrier function. Am. J. Physiol.-Gastrointest. Liver Physiol. 2010, 298, G807–G819. [Google Scholar] [CrossRef]
  30. Rivière, A.; Selak, M.; Lantin, D.; Leroy, F.; De Vuyst, L. Bifidobacteria and butyrate-producing colon bacteria: Importance and strategies for their stimulation in the human gut. Front. Microbiol. 2016, 7, 979. [Google Scholar] [CrossRef]
  31. Jäger, R.; Mohr, A.E.; Carpenter, K.C.; Kerksick, C.M.; Purpura, M.; Moussa, A.; Townsend, J.R.; Lamprecht, M.; West, N.P.; Black, K. International society of sports nutrition position stand: Probiotics. J. Int. Soc. Sports Nutr. 2019, 16, 62. [Google Scholar] [CrossRef]
  32. Santibanez-Gutierrez, A.; Fernandez-Landa, J.; Calleja-Gonzalez, J.; Delextrat, A.; Mielgo-Ayuso, J. Effects of Probiotic Supplementation on Exercise with Predominance of Aerobic Metabolism in Trained Population: A Systematic Review, Meta-Analysis and Meta-Regression. Nutrients 2022, 14, 622. [Google Scholar] [CrossRef]
  33. Przewłócka, K.; Kujach, S.; Sawicki, P.; Berezka, P.; Bytowska, Z.K.; Folwarski, M.; Kowalski, K.; Kaczor, J.J. Effects of Probiotics and Vitamin D3 Supplementation on Sports Performance Markers in Male Mixed Martial Arts Athletes: A Randomized Trial. Sports Med.-Open 2023, 9, 31. [Google Scholar] [CrossRef] [PubMed]
  34. Wiącek, J.; Karolkiewicz, J. Different Approaches to Ergogenic, Pre-, and Probiotic Supplementation in Sports with Different Metabolism Characteristics: A Mini Review. Nutrients 2023, 15, 1541. [Google Scholar] [CrossRef]
  35. Schreiber, C.; Tamir, S.; Golan, R.; Weinstein, A.; Weinstein, Y. The effect of probiotic supplementation on performance, inflammatory markers and gastro-intestinal symptoms in elite road cyclists. J. Int. Soc. Sports Nutr. 2021, 18, 36. [Google Scholar] [CrossRef] [PubMed]
  36. Gibson, G.R.; Hutkins, R.; Sanders, M.E.; Prescott, S.L.; Reimer, R.A.; Salminen, S.J.; Scott, K.; Stanton, C.; Swanson, K.S.; Cani, P.D. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat. Rev. Gastroenterol. Hepatol. 2017, 14, 491–502. [Google Scholar] [CrossRef] [PubMed]
  37. Bongiovanni, T.; Yin, M.O.L.; Heaney, L.M. The athlete and gut microbiome: Short-chain fatty acids as potential ergogenic aids for exercise and training. Int. J. Sports Med. 2021, 42, 1143–1158. [Google Scholar]
  38. Makki, K.; Deehan, E.C.; Walter, J.; Bäckhed, F. The impact of dietary fiber on gut microbiota in host health and disease. Cell Host Microbe 2018, 23, 705–715. [Google Scholar] [CrossRef]
  39. Healey, G.; Murphy, R.; Butts, C.; Brough, L.; Whelan, K.; Coad, J. Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: A randomised, double-blind, placebo-controlled, cross-over, human intervention study. Br. J. Nutr. 2018, 119, 176–189. [Google Scholar] [CrossRef]
  40. Shanahan, F. Fiber man meets microbial man. Am. J. Clin. Nutr. 2015, 101, 1–2. [Google Scholar] [CrossRef]
  41. Eswaran, S.; Muir, J.; Chey, W.D. Fiber and functional gastrointestinal disorders. Off. J. Am. Coll. Gastroenterol.|ACG 2013, 108, 718–727. [Google Scholar] [CrossRef]
  42. Clarke, G.; Stilling, R.M.; Kennedy, P.J.; Stanton, C.; Cryan, J.F.; Dinan, T.G. Minireview: Gut microbiota: The neglected endocrine organ. Mol. Endocrinol. 2014, 28, 1221–1238. [Google Scholar] [CrossRef] [PubMed]
  43. Gaudier, E.; Forestier, L.; Gouyer, V.; Huet, G.; Julien, R.; Hoebler, C. Butyrate regulation of glycosylation-related gene expression: Evidence for galectin-1 upregulation in human intestinal epithelial goblet cells. Biochem. Biophys. Res. Commun. 2004, 325, 1044–1051. [Google Scholar] [CrossRef] [PubMed]
  44. Khan, S.; Jena, G. Sodium butyrate, a HDAC inhibitor ameliorates eNOS, iNOS and TGF-β1-induced fibrogenesis, apoptosis and DNA damage in the kidney of juvenile diabetic rats. Food Chem. Toxicol. 2014, 73, 127–139. [Google Scholar] [CrossRef]
  45. Lahiri, S.; Kim, H.; Garcia-Perez, I.; Reza, M.M.; Martin, K.A.; Kundu, P.; Cox, L.M.; Selkrig, J.; Posma, J.M.; Zhang, H. The gut microbiota influences skeletal muscle mass and function in mice. Sci. Transl. Med. 2019, 11, eaan5662. [Google Scholar] [CrossRef] [PubMed]
  46. Okamoto, T.; Morino, K.; Ugi, S.; Nakagawa, F.; Lemecha, M.; Ida, S.; Ohashi, N.; Sato, D.; Fujita, Y.; Maegawa, H. Microbiome potentiates endurance exercise through intestinal acetate production. Am. J. Physiol.-Endocrinol. Metab. 2019, 316, E956–E966. [Google Scholar] [CrossRef] [PubMed]
  47. Salminen, S.; Collado, M.C.; Endo, A.; Hill, C.; Lebeer, S.; Quigley, E.M.; Sanders, M.E.; Shamir, R.; Swann, J.R.; Szajewska, H. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat. Rev. Gastroenterol. Hepatol. 2021, 18, 649–667. [Google Scholar] [CrossRef]
  48. Aguilar-Toalá, J.; Garcia-Varela, R.; Garcia, H.; Mata-Haro, V.; González-Córdova, A.; Vallejo-Cordoba, B.; Hernández-Mendoza, A. Postbiotics: An evolving term within the functional foods field. Trends Food Sci. Technol. 2018, 75, 105–114. [Google Scholar] [CrossRef]
  49. Macfarlane, S.; Macfarlane, G.T. Regulation of short-chain fatty acid production. Proc. Nutr. Soc. 2003, 62, 67–72. [Google Scholar] [CrossRef]
  50. Topping, D.L.; Clifton, P.M. Short-chain fatty acids and human colonic function: Roles of resistant starch and nonstarch polysaccharides. Physiol. Rev. 2001, 81, 1031–1064. [Google Scholar] [CrossRef]
  51. Hamer, H.M.; Jonkers, D.; Venema, K.; Vanhoutvin, S.; Troost, F.; Brummer, R.J. The role of butyrate on colonic function. Aliment. Pharmacol. Ther. 2008, 27, 104–119. [Google Scholar] [CrossRef]
  52. Jørgensen, J.; Clausen, M.; Mortensen, P. Oxidation of short and medium chain C2-C8 fatty acids in Sprague-Dawley rat colonocytes. Gut 1997, 40, 400–405. [Google Scholar] [CrossRef] [PubMed]
  53. Brown, A.J.; Goldsworthy, S.M.; Barnes, A.A.; Eilert, M.M.; Tcheang, L.; Daniels, D.; Muir, A.I.; Wigglesworth, M.J.; Kinghorn, I.; Fraser, N.J. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J. Biol. Chem. 2003, 278, 11312–11319. [Google Scholar] [CrossRef]
  54. Silva, Y.P.; Bernardi, A.; Frozza, R.L. The role of short-chain fatty acids from gut microbiota in gut-brain communication. Front. Endocrinol. 2020, 11, 25. [Google Scholar] [CrossRef] [PubMed]
  55. Sakakibara, I.; Fujino, T.; Ishii, M.; Tanaka, T.; Shimosawa, T.; Miura, S.; Zhang, W.; Tokutake, Y.; Yamamoto, J.; Awano, M. Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. Cell Metab. 2009, 9, 191–202. [Google Scholar] [CrossRef] [PubMed]
  56. Huang, L.; Li, T.; Zhou, M.; Deng, M.; Zhang, L.; Yi, L.; Zhu, J.; Zhu, X.; Mi, M. Hypoxia improves endurance performance by enhancing short chain fatty acids production via gut microbiota remodeling. Front. Microbiol. 2022, 12, 820691. [Google Scholar] [CrossRef]
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Toon, A.; Bailey, S.; Roelands, B. Effects of Nutritional Interventions on Athletic Performance. Nutrients 2023, 15, 4498. https://doi.org/10.3390/nu15214498

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Toon A, Bailey S, Roelands B. Effects of Nutritional Interventions on Athletic Performance. Nutrients. 2023; 15(21):4498. https://doi.org/10.3390/nu15214498

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Toon, Ampe, Stephen Bailey, and Bart Roelands. 2023. "Effects of Nutritional Interventions on Athletic Performance" Nutrients 15, no. 21: 4498. https://doi.org/10.3390/nu15214498

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